1-833-ZEPOSIA

ZEPOSIA is a once-daily pill for adults with moderate to severe ulcerative colitis (UC).

Take as directed by your doctor if certain liver problems exist.

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ZEPOSIA is a once-daily pill for adults with moderate to severe ulcerative colitis (UC).

Take as directed by your doctor if certain liver problems exist.

What does it cost to take ZEPOSIA?

Generally, your out-of-pocket costs related to taking ZEPOSIA are determined by your insurance coverage and benefits, such as deductibles and co-insurance. This information is intended to help you understand the costs of ZEPOSIA.

ZEPOSIA® pill icon

Medication costs

  • The list price for the ZEPOSIA Starter Kit (the initial 28-dose supply) is $7,827.56
  • For a 30-dose supply of ZEPOSIA (regular daily dosage), the list price is $8,386.66
  • A co-pay savings offer is available to eligible, commercially insured patients
Financial support assistance icon

Medical costs

  • If you have commercial insurance, you may be eligible for reimbursement of out-of-pocket medical costs associated with getting started with ZEPOSIA

A Support Coordinator can help you better understand your costs and what financial support options are available to you.

Additional eligibility requirements and terms & conditions apply. Please click here for more information.

Which type of insurance coverage do you have?

ZEPOSIA prescription costs:

Your out-of-pocket costs for ZEPOSIA will be determined by your insurance coverage. But depending on your coverage and financial need, there may be ways to save on the cost of ZEPOSIA and the tests needed before treatment.

Additional eligibility requirements and terms & conditions apply. Please click here for more information.

ZEPOSIA® Co-pay Program icon

The co-pay savings offer

Eligible, commercially insured patients may pay as little as $0 a month for ZEPOSIA. Additional eligibility requirements and terms & conditions apply. Please click here for more information.

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Costs for tests before treatment

Before you can begin taking ZEPOSIA, some routine testing is required. The tests can be done at a healthcare professional's office or at your home if you're eligible*:

Blood work—including complete blood count and liver function tests.

An electrocardiogram (ECG)—a common test that uses small sensors to monitor your heart and makes sure it’s working normally before you start treatment.

An eye exam—this may only be required for people with a history of macular edema, uveitis, or diabetes.

There may be costs associated with some of the routine medical tests, but depending on where these tests take place, eligible patients may qualify for reimbursement or incur no costs at all. Additional eligibility requirements and terms & conditions apply. Please click here for more information.


If you’re eligible, how will you be reimbursed?

If you accrue any costs associated with office visits (co-pay) or routine medical tests when starting ZEPOSIA, here’s what to do:

1 Save all the receipts related to the costs of your office visits and routine medical tests when starting treatment.
2 Save your Explanation of Benefits (EOB) form from your insurance carrier (it will be mailed or e-mailed to you).
3 Call 1-833-ZEPOSIA (833-937-6742) to initiate a medical rebate request. Once a benefits review is completed and your eligibility is confirmed, a representative will send you a personalized rebate form by mail.
4 Mail all receipts, EOB form, and the completed rebate form to the address specified on the form.
5 You’ll receive a check in the mail reimbursing you for what you paid (if eligible).
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Get ZEPOSIA while you wait for insurance approval

The ZEPOSIA Bridge Program may provide help for eligible, commercially insured patients who are experiencing a delay in obtaining coverage or have been denied coverage.

ZEPOSIA® 360 Support - support coordinator icon

Our Support Coordinators are available to help

1-833-ZEPOSIA (1-833-937-6742), Monday to Friday, 8 AM - 8 PM ET.

  • Patient must have a valid prescription for ZEPOSIA for an FDA-approved indication. Patients are not eligible if they have prescription insurance coverage through a state or federal healthcare program, including but not limited to Medicare, Medicaid, Medigap, CHAMPUS, TRICARE, Veterans Affairs (VA), or Department of Defense (DoD) programs, or reside in Rhode Island. To receive the In-Home Medical Services Program, the prescriber must request in-home assessment assistance through the ZEPOSIA 360 Support program. The patient’s insurance will not be billed, and the patient will not be responsible for any out-of-pocket costs. Patients who move from commercial plans to state or federal healthcare programs will no longer be eligible. The program cannot be combined with any other offer, rebate, coupon, or free trial. The program is not conditioned on any past, present, or future purchase, including refills. Only valid in the United States and US Territories. Void where prohibited by law, taxed, or restricted. The program is not insurance. Bristol-Myers Squibb Company reserves the right to rescind, revoke, or amend this program at any time without notice. Other limitations may apply.
  • The Bridge Program is available at no cost for eligible, commercially insured, on-label diagnosed patients if there is a delay in determining whether commercial prescription coverage is available, and is not contingent on any purchase requirement, for up to 24 months (dispensed in 30-day increments). The Bridge Program is not available to patients who have prescription insurance coverage through a state or federal healthcare program, including but not limited to Medicare, Medicaid, Medigap, CHAMPUS, TRICARE, Veterans Affairs (VA), or Department of Defense (DoD) programs and is available for no more than 12 months to patients in MA, MN, and RI. Appeal of any prior authorization denial must be made within 90 days or as per payer guidelines, to remain in the program. Eligibility will be re-verified in January for patients continuing into the following year, and may be at other times during program participation. Offer is not health insurance. Once coverage is approved by the patient’s commercial insurance plan, the patient will no longer be eligible. Void where prohibited by law, taxed, or restricted. Bristol-Myers Squibb Company reserves the right to rescind, revoke, or amend this program at any time without notice. Other limitations may apply.
  • While Support Coordinators can answer questions about ZEPOSIA 360 Support, they can not provide medical advice.

When covered, people who have prescription insurance through Medicare may pay $0 to $2,475.42 per month for ZEPOSIA.

Your costs are determined by your pharmacy coverage, such as Medicare Part D, Medicare Advantage (Part C), your coverage phase, and your income level. Use this link to learn about costs for Medicare drug coverage.

Certain patients may be eligible for the Low-Income Subsidy, also known as “Extra Help.” Use this link to learn more.

Your out-of-pocket costs for ZEPOSIA are determined by your insurance provider. To find out what your costs may be, please call a Support Coordinator (information below).*

ZEPOSIA® 360 Support - support coordinator icon

Our Support Coordinators are available to help

1-833-ZEPOSIA (833-937-6742), Monday to Friday, 8 AM - 8 PM ET.

  • While Support Coordinators can answer questions about ZEPOSIA 360 Support, they can not provide medical advice.

Costs for tests before treatment

Before you can begin taking ZEPOSIA, some routine testing is required:

Blood work—including complete blood count and liver function tests.

An electrocardiogram (ECG)—a common test that uses small sensors to monitor your heart and makes sure it’s working normally before you start treatment.

An eye exam—this may only be required for people with a history of macular edema, uveitis, or diabetes.

Regardless of where these appointments take place, you will pay what you normally would for an in-network office visit and/or tests.

If you do not have prescription drug coverage or your insurance does not cover ZEPOSIA, you can expect to pay the list price for ZEPOSIA of $7,636.64 for the ZEPOSIA Starter Kit (the initial 28-dose supply) or $8,182.00 for a 30-dose supply of the regular daily dosage of ZEPOSIA per month, with any additional pharmacy charges or discounts based on where you purchase your medicine.

If you’re uninsured or underinsured, and need assistance with co-pay or ZEPOSIA treatment costs, please reach out to a Support Coordinator to learn about the options available to you.

ZEPOSIA® 360 Support - support coordinator icon

Our Support Coordinators are available to help

1-833-ZEPOSIA (1-833-937-6742), Monday to Friday, 8 AM - 8 PM ET.

  • While Support Coordinators can answer questions about ZEPOSIA 360 Support, they can not provide medical advice.