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ZEPOSIA® (ozanimod) is a prescription medicine used to treat moderately to severely active ulcerative colitis (UC) in adults.
It is not known if ZEPOSIA is safe and effective in children.
ZEPOSIA® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
It is not known if ZEPOSIA is safe and effective in children.
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It’s important to tell your UC healthcare provider about any other medicines or supplements that you’re taking or have recently taken, including:
Using ZEPOSIA with other medicines can cause serious side effects.
Especially tell your UC healthcare provider if you take or have taken other medicines, such as:
You can start treatment with ZEPOSIA after taking a few routine tests. If you’ve received some of these tests in the last six months, speak to your healthcare provider, as they may not need to be repeated:
An eye exam may also be needed for people with a history of macular edema or uveitis.
The ZEPOSIA Prescribing Information does not require ongoing lab monitoring unless indicated by your healthcare provider.
If you plan to complete all of the tests in one visit at a healthcare provider's office, it may take as little as 1 hour to complete. If your appointment is at home, please be available for up to 2 hours.*
Costs associated with your appointment will vary, depending on your insurance coverage. For eligible patients, these costs may be reimbursed, or you may pay nothing at all. To learn more, speak with your UC Nurse Navigator or explore ZEPOSIA cost information.
Patient must have a valid prescription for ZEPOSIA for an FDA-approved indication. Patient must be new to therapy and have not previously received a sample or filled a prescription for ZEPOSIA. Patient is responsible for applicable taxes, if any. This offer is limited to one use per patient per lifetime and is non-transferable. Cannot be combined with any other rebate/coupon, free trial, or similar offer. No substitutions permitted. Patients, pharmacists, and prescribers cannot seek reimbursement for the ZEPOSIA Free Trial from health insurance or any third party, including state or federally funded programs. Patients may not count the ZEPOSIA Free Trial as an expense incurred for purposes of determining out-of-pocket costs for any plan, including Medicare Part D true out-of-pocket costs (TrOOP). Offer is not conditioned on any past, present, or future purchase, including refills. Only valid in the United States and US Territories. Void where prohibited by law or restricted. The program is not insurance. Bristol Myers Squibb reserves the right to rescind, revoke, or amend this offer at any time without notice.
You should not receive live vaccines during treatment with ZEPOSIA, for at least 1 month before taking ZEPOSIA, and for
3 months after you stop taking ZEPOSIA. Vaccines may not work as well when given during treatment with ZEPOSIA.
Talk to your UC healthcare provider before receiving any vaccines while on ZEPOSIA.
See the question below for information about the varicella zoster virus (VZV) vaccine and taking ZEPOSIA.
Your doctor may require you to receive the varicella zoster virus (VZV) vaccine, also known as the chickenpox vaccine, before you take ZEPOSIA. The VZV vaccine includes two doses. If you haven't received the VZV vaccine in the past, you may need to postpone the start of treatment with ZEPOSIA.
If you're unsure of your vaccination status, there is a test that can determine whether or not you've already received the VZV vaccine, have had chickenpox, or have received the vaccine for chickenpox. Your healthcare provider may do a blood test for the chickenpox virus. You may need to get the full course of the vaccine for chickenpox and then wait 1 month before you start taking ZEPOSIA.
You should take ZEPOSIA exactly as prescribed by your UC healthcare provider.
If you miss 1 or more doses during the first 14 days of treatment, contact your UC healthcare provider. You’ll need a new 7-day Starter Pack to restart treatment. This will allow you to increase your dosage gradually to help avoid a decrease in heart rate, which is a possible serious side effect of ZEPOSIA.
If you miss a dose after the first
14 days of treatment, take your scheduled dose (1 pill) the next day at your usual time.
A missed dose is when you don’t take ZEPOSIA for a full calendar day.
Tyramine (TIE-ruh-meen) is a type of compound (monoamine compound) found naturally in the body. It can also be found in high amounts in certain foods and beverages. Consuming a large amount of tyramine while taking ZEPOSIA could lead to severe high blood pressure (hypertension).
It’s recommended that people taking ZEPOSIA avoid foods and beverages that have more than 150 mg of tyramine. The following foods may be high in tyramine and should be avoided:
Click here for a list of common high-tyramine foods and beverages
The list includes the amount of tyramine per serving, as well as the amount of each food and beverage that could contain
Keep in mind, consuming multiple foods and beverages with any level of tyramine in them could result in a high amount
of tyramine in the body.
Please note that different people react to tyramine differently. Speak with your healthcare provider before making any changes to your diet.
You and your healthcare provider should work together to make sure ZEPOSIA is right for you before starting treatment. Be sure to let your healthcare provider know if you have any of these conditions or do not know if you have any of these conditions before taking ZEPOSIA:
Talk with your healthcare provider if you are pregnant or plan to become pregnant. If you are a female who can become pregnant, you should use effective birth control during your treatment with ZEPOSIA and for
3 months after you stop taking ZEPOSIA.
Tell your healthcare provider right away if you become pregnant while taking ZEPOSIA or if you become pregnant within 3 months after you stop taking ZEPOSIA.
If you are a female who can become pregnant, you should use effective birth control during your treatment with ZEPOSIA and for
3 months after you stop taking ZEPOSIA. Talk with your healthcare provider about what birth control method is right for you during this time.
If you have private or commercial insurance, you may be eligible to pay as little as $0 a month for your ZEPOSIA prescription. View co-pay terms & conditions.
You can sign up and determine if you’re eligible in two ways:
Before you begin treatment, your UC Nurse Navigator will help you understand your medical and pharmacy benefits.
If you have private or commercial insurance and are experiencing delays or issues with coverage, the ZEPOSIA Bridge Program may be able to provide ZEPOSIA to you for free, as needed, until these issues are resolved (for up to
24 months).*
The Bridge Program is available at no cost for eligible, commercially insured, on-label diagnosed patients if there is a delay in determining whether commercial prescription coverage is available, and is not contingent on any purchase requirement, for up to 24 months (dispensed in 30-day increments). The Bridge Program is not available to patients who have prescription insurance coverage through a state or federal healthcare program, including but not limited to Medicare, Medicaid, Medigap, CHAMPUS, TRICARE, Veterans Affairs (VA), or Department of Defense (DoD) programs and is available for no more than 12 months to patients in MA, MN, and RI. Appeal of any prior authorization denial must be made within 90 days or as per payer guidelines, to remain in the program. Eligibility will be re-verified in January for patients continuing into the following year, and may be at other times during program participation. Offer is not health insurance. Once coverage is approved by the patient’s commercial insurance plan, the patient will no longer be eligible. Void where prohibited by law, taxed, or restricted. Bristol-Myers Squibb Company reserves the right to rescind, revoke, or amend this program at any time without notice. Other limitations may apply.
Those who are eligible may
pay as
little as $0 a month
for ZEPOSIA
with a co-pay savings offer. View
co-pay terms & conditions.
Sign up for the latest
ZEPOSIA
details,
UC tips, stories from real
people taking ZEPOSIA,
and more
from
ZEPOSIA 360 SupportTM.
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Do not take ZEPOSIA if you:
Talk to your healthcare provider before taking ZEPOSIA if you have any of these conditions or do not know if you have any of these conditions.
ZEPOSIA may cause serious side effects, including:
Call your healthcare provider right away if you have any of these symptoms of an infection during treatment with ZEPOSIA and for 3 months after your last dose of ZEPOSIA:
Your healthcare provider may delay starting or may stop your ZEPOSIA treatment if you have an infection.
Progressive multifocal leukoencephalopathy (PML). ZEPOSIA can increase your risk for PML, which is a rare brain infection that usually leads to death or severe disability. If PML happens, it usually happens in people with weakened immune systems but has happened in people who do not have weakened immune systems. Symptoms of PML get worse over days to weeks. Call your doctor right away if you have any new or worsening symptoms of PML that have lasted several days, including: weakness on one (1) side of your body, changes in your vision, changes in your thinking or memory, confusion, changes in your personality, loss of coordination in your arms or legs, decreased strength, and/or problems with balance.
Call your healthcare provider if you experience the following symptoms of slow heart rate:
Follow directions from your healthcare provider when starting ZEPOSIA and when you miss a dose.
Continue reading for additional possible serious side effects of ZEPOSIA.
Before taking ZEPOSIA, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take or have recently taken, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using ZEPOSIA with other medicines can cause serious side effects. Especially tell your healthcare provider if you take or have taken:
You should not receive live vaccines during treatment with ZEPOSIA, for at least 1 month before taking ZEPOSIA and for 3 months after you stop taking ZEPOSIA. Vaccines may not work as well when given during treatment with ZEPOSIA.
ZEPOSIA can cause serious side effects, including:
The most common side effects of ZEPOSIA can include:
These are not all of the possible side effects of ZEPOSIA. For more information, ask your healthcare provider or pharmacist.
Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 1-800-FDA-1088.
Multiple Sclerosis (MS): ZEPOSIA® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
Ulcerative Colitis (UC): ZEPOSIA is a prescription medicine used to treat moderately to severely active ulcerative colitis (UC) in adults.
It is not known if ZEPOSIA is safe and effective in children.
Please see full Prescribing Information, including Medication Guide.
Do not take ZEPOSIA if you:
Talk to your healthcare provider before taking ZEPOSIA if you have any of these conditions or do not know if you have any of these conditions.
ZEPOSIA may cause serious side effects, including: