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1-833-ZEPOSIA

ZEPOSIA is a once-daily pill for adults with moderate to severe ulcerative colitis (UC).

Take as directed by your doctor if certain liver problems exist.

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ZEPOSIA is a once-daily pill for adults with moderate to severe ulcerative colitis (UC).

Take as directed by your doctor if certain liver problems exist.

4 steps to getting started with ZEPOSIA

There are a few steps to getting started with ZEPOSIA. They will begin once your Start Form (your ZEPOSIA prescription) is submitted.

1 Your Support Coordinator 2 Initial routine tests 3 The ZEPOSIA Starter Kit 4 Getting ZEPOSIA delivered
1 A call from a Support Coordinator
ZEPOSIA® 360 Support - support coordinator icon

If your start form was submitted to the ZEPOSIA 360 Support ProgramTM, a Support Coordinator will call to guide you through the support offerings and financial assistance options available to you. Consider adding this number to your phone so you can identify the call: 1-833-937-6742.

Our Support Coordinators can help with:

Navigating insurance benefits*

  • Depending on your insurance coverage and financial needs, there may be several different ways to save on the cost of ZEPOSIA and the tests needed before treatment. Our Support Coordinators can help you understand your options
  • If you have private or commercial insurance and are experiencing delays or issues with coverage, the ZEPOSIA Bridge Program† may be able to provide ZEPOSIA to you, as needed (for up to 24 months). Additional eligibility requirements and terms & conditions apply

Additional financial support options

  • Eligible, commercially insured patients may pay as little as $0 a month for ZEPOSIA. Additional eligibility requirements and terms & conditions apply. Please click here for more information
  • If you have difficulty affording your medication, our Support Coordinators can help you identify options that may be available to you

Additional support team members are also available to answer questions about ZEPOSIA and provide helpful resources.

1-833-ZEPOSIA (1-833-937-6742), Monday to Friday, 8 AM – 8 PM ET.

If you haven’t heard from a Support Coordinator, touch base with your healthcare provider to ensure that your Start Form was submitted to ZEPOSIA 360 Support.

Being enrolled in ZEPOSIA 360 Support helps you access the support you need throughout your entire treatment journey.

  • The accurate completion of reimbursement- or coverage-related documentation is the responsibility of the healthcare provider and patient. Bristol Myers Squibb and its agents make no guarantee regarding reimbursement for any service or item.
  • Additional eligibility requirements and terms and conditions apply. Please see ZEPOSIA Bridge Program Terms and Conditions.
2 Routine tests to get started
Stethoscope icon

Before you start taking ZEPOSIA, two routine tests are required. If you have a history of certain eye conditions (macular edema or uveitis), or diabetes, you may also need an eye exam. Let your healthcare provider know if you’ve had some of these tests within the last six months—they may not need to be repeated:

Blood work icon

Blood work

Including complete blood count and liver function tests.

ECG icon

An electrocardiogram (ECG)

A common test that uses small sensors to monitor your heart and makes sure it's working normally before you start treatment.

Tell your UC healthcare provider about all the medications you take, have recently taken, and if you’ve had chickenpox or received the chickenpox vaccine. You may be asked to do a blood test for the chickenpox virus. You may need to get the full course of the vaccine, then wait 1 month before taking ZEPOSIA.

  • These tests can be completed at your home‡, if you're eligible. ZEPOSIA 360 Support can help schedule them
  • Out-of-pocket costs may be eligible for reimbursement. There may be costs associated with some of the routine medical tests, but depending on where these tests take place, eligible, commercially insured patients may qualify for reimbursement. Additional eligibility requirements and terms & conditions apply. Please click here for more information

The ZEPOSIA Prescribing Information does not require ongoing lab monitoring unless indicated by your healthcare provider.

Trey, real ZEPOSIA® patient
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Once I was prescribed ZEPOSIA, ZEPOSIA 360 Support arranged for a clinician to come to my house to do all the necessary tests.‡

—Trey
A real ZEPOSIA patient compensated for his time.

See Trey’s story
  • Additional eligibility requirements and terms and conditions apply. Please see ZEPOSIA In-Home Medical Services Program Terms and Conditions.
3 Begin treatment with the Starter Kit
ZEPOSIA® pill icon

A gradual start designed with you in mind

Once you’ve been approved to begin treatment, you’ll receive the ZEPOSIA Starter Kit. It will either be provided to you by your healthcare provider or delivered directly to your home. Please see additional eligibility requirements and terms and conditions.§

The ZEPOSIA Starter Kit includes medication for you to begin treatment and has two parts:

ZEPOSIA® 7-day starter pack image
  1. A 7-day Starter Pack for your first week of treatment. The pills in this pack help increase your dosage of ZEPOSIA gradually. Each pill is labeled with the day and dosage. Be sure to follow the instructions written on the pack and take the pills in the correct order
  2. The regular dosage of ZEPOSIA (orange capsules) you’ll begin taking on day 8 (after completing the 7-day Starter Pack)

If you have private or commercial insurance and are experiencing delays or issues with coverage, the ZEPOSIA Bridge Program may be able to provide ZEPOSIA to you for free, as needed, until these issues are resolved (for up to 24 months).†

  • Additional eligibility requirements and terms and conditions apply. Please see ZEPOSIA Free Trial Terms and Conditions.
4 Getting ZEPOSIA delivered to you
Specialty Pharmacy delivery truck icon

You’ll receive a call from your specialty pharmacy A specialty pharmacy is different than a regular retail pharmacy. It distributes medications for certain chronic conditions and delivers them directly to you. Some specialty pharmacies also offer in-store pickup. to confirm the delivery of your ZEPOSIA prescription each month. If you prefer to pick up your prescription in store, simply ask your specialty pharmacy. They may offer that option.

Hand holding mobile phone with apps icon

An app to help you get started and stay on track

The Redi.Health for ZEPOSIA app is a tool that can help support you on your UC journey. It includes medication tracking, UC-friendly recipes, information on ZEPOSIA, and more.

Get started by downloading the Redi.Health app from your mobile device and entering code ZEPOSIA.

Download on Apple Store button Download on Google Play button

Rather use the online version? Click here to sign up and get started.

See if you could save on treatment costs

Those who are eligible and commercially insured may pay as little as $0 a month for ZEPOSIA with a co-pay savings offer. Additional eligibility requirements and terms & conditions apply. Please click here for more information.

Enroll now

Once you start treatment, stay on track

Sign up for ZEPOSIA 360 Support communications to receive resources, information, and support for starting and staying on treatment.

Sign up now

IMPORTANT SAFETY INFORMATION

Do not take ZEPOSIA if you:

  • have had a heart attack, chest pain (unstable angina), stroke or mini-stroke (transient ischemic attack or TIA), or certain types of heart failure in the last 6 months
  • have or have had a history of certain types of an irregular or abnormal heartbeat (arrhythmia) that is not corrected by a pacemaker
  • have untreated, severe breathing problems during your sleep (sleep apnea)
  • take certain medicines called monoamine oxidase (MAO) inhibitors (such as selegiline, phenelzine, linezolid)

Talk to your healthcare provider before taking ZEPOSIA if you have any of these conditions or do not know if you have any of these conditions.

ZEPOSIA may cause serious side effects, including:

  • Infections. ZEPOSIA can increase your risk of serious infections that can be life-threatening and cause death. ZEPOSIA lowers the number of white blood cells (lymphocytes) in your blood. This will usually go back to normal within 3 months of stopping treatment. Your healthcare provider may do a blood test of your white blood cells before you start taking ZEPOSIA.

    Call your healthcare provider right away if you have any of these symptoms of an infection during treatment with ZEPOSIA and for 3 months after your last dose of ZEPOSIA:

    • fever
    • feeling very tired
    • flu-like symptoms
    • cough
    • painful and frequent urination (signs of a urinary tract infection)
    • rash
    • headache with fever, neck stiffness, sensitivity to light, nausea, or confusion (these may be symptoms of meningitis, an infection of the lining around your brain and spine)

    Your healthcare provider may delay starting or may stop your ZEPOSIA treatment if you have an infection.

  • Progressive multifocal leukoencephalopathy (PML). ZEPOSIA can increase your risk for PML, which is a rare brain infection that usually leads to death or severe disability. If PML happens, it usually happens in people with weakened immune systems but has happened in people who do not have weakened immune systems. Symptoms of PML get worse over days to weeks. Call your doctor right away if you have any new or worsening symptoms of PML that have lasted several days, including: weakness on one (1) side of your body, changes in your vision, changes in your thinking or memory, confusion, changes in your personality, loss of coordination in your arms or legs, decreased strength, and/or problems with balance.
  • Slow heart rate (also known as bradyarrhythmia) when you start taking ZEPOSIA. ZEPOSIA may cause your heart rate to temporarily slow down, especially during the first 8 days. You will have a test to check the electrical activity of your heart called an electrocardiogram (ECG) before you take your first dose of ZEPOSIA.

    Call your healthcare provider if you experience the following symptoms of slow heart rate:

    • dizziness
    • lightheadedness
    • feeling like your heart is beating slowly or skipping beats
    • shortness of breath
    • confusion
    • chest pain
    • tiredness

Follow directions from your healthcare provider when starting ZEPOSIA and when you miss a dose.

Continue reading for additional possible serious side effects of ZEPOSIA.

Before taking ZEPOSIA, tell your healthcare provider about all of your medical conditions, including if you:

  • have a fever or infection, or are unable to fight infections due to a disease, or take or have taken medicines that lower your immune system
  • received a vaccine in the past 30 days or are scheduled to receive a vaccine. ZEPOSIA may cause vaccines to be less effective
  • before you start ZEPOSIA, your healthcare provider may give you a chickenpox (Varicella Zoster Virus) vaccine if you have not had one before
  • have had chickenpox or have received the vaccine for chickenpox. Your healthcare provider may do a blood test for the chickenpox virus. You may need to get the full course of the vaccine and wait 1 month before taking ZEPOSIA
  • have a slow heart rate
  • have an irregular or abnormal heartbeat (arrhythmia)
  • have a history of stroke
  • have or have had heart problems, including a heart attack or chest pain
  • have high blood pressure
  • have liver problems
  • have breathing problems, including during your sleep
  • have eye problems, especially an inflammation of the eye called uveitis
  • have diabetes
  • are or plan to become pregnant or if you become pregnant within 3 months after you stop taking ZEPOSIA. ZEPOSIA may harm your unborn baby. If you are a female who can become pregnant, talk to your healthcare provider about what birth control method is right for you during your treatment with ZEPOSIA and for 3 months after you stop taking ZEPOSIA. If you become pregnant while taking ZEPOSIA for MS, tell your healthcare provider right away and enroll in the ZEPOSIA Pregnancy Registry by calling 1-877-301-9314 or visiting www.zeposiapregnancyregistry.com
  • are breastfeeding or plan to breastfeed. It is not known if ZEPOSIA passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take ZEPOSIA

Tell your healthcare provider about all the medicines you take or have recently taken, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using ZEPOSIA with other medicines can cause serious side effects. Especially tell your healthcare provider if you take or have taken:

  • medicines that affect your immune system, such as alemtuzumab
  • medicines to control your heart rhythm (antiarrhythmics), or heartbeat
  • CYP2C8 inducers such as rifampin
  • CYP2C8 inhibitors such as gemfibrozil (medicine to treat high fat in your blood)
  • opioids (pain medicine), medicines to treat depression, and medicines to treat Parkinson’s disease
  • medicines to control your heart rate and blood pressure (beta blocker medicines and calcium channel blocker medicines)

You should not receive live vaccines during treatment with ZEPOSIA, for at least 1 month before taking ZEPOSIA and for 3 months after you stop taking ZEPOSIA. Vaccines may not work as well when given during treatment with ZEPOSIA.

ZEPOSIA can cause serious side effects, including:

  • liver problems. Your healthcare provider will do blood tests to check your liver before you start taking ZEPOSIA. Call your healthcare provider right away if you have any of the following symptoms:
    • unexplained nausea
    • vomiting
    • stomach area (abdominal) pain
    • tiredness
    • loss of appetite
    • yellowing of the whites of your eyes or skin
    • dark colored urine
  • increased blood pressure. Your healthcare provider should check your blood pressure during treatment with ZEPOSIA. A sudden, severe increase in blood pressure (hypertensive crisis) can happen when you eat certain foods that contain high levels of tyramine.
  • breathing problems. Some people who take ZEPOSIA have shortness of breath. Call your healthcare provider right away if you have new or worsening breathing problems.
  • a problem with your vision called macular edema. Your risk of macular edema is higher if you have diabetes or have had an inflammation of your eye called uveitis. Your healthcare provider should test your vision before you start taking ZEPOSIA if you are at higher risk for macular edema or any time you notice vision changes during treatment with ZEPOSIA. Call your healthcare provider right away if you have any of the following symptoms:
    • blurriness or shadows in the center of your vision
    • sensitivity to light
    • a blind spot in the center of your vision
    • unusually colored vision
  • swelling and narrowing of the blood vessels in your brain. Posterior Reversible Encephalopathy Syndrome (PRES) is a rare condition that has happened with ZEPOSIA and with drugs in the same class. Symptoms of PRES usually get better when you stop taking ZEPOSIA. If left untreated, it may lead to stroke. Your healthcare provider will do a test if you have any symptoms of PRES. Call your healthcare provider right away if you have any of the following symptoms:
    • sudden severe headache
    • sudden confusion
    • sudden loss of vision or other changes in your vision
    • seizure
  • severe worsening of multiple sclerosis (MS) after stopping ZEPOSIA. When ZEPOSIA is stopped, symptoms of MS may return and become worse compared to before or during treatment. Always talk to your healthcare provider before you stop taking ZEPOSIA for any reason. Tell your healthcare provider if you have worsening symptoms of MS after stopping ZEPOSIA.

The most common side effects of ZEPOSIA can include:

  • upper respiratory tract infections
  • elevated liver enzymes
  • low blood pressure when you stand up (orthostatic hypotension)
  • painful and frequent urination (signs of urinary tract infection)
  • back pain
  • high blood pressure
  • headache

These are not all of the possible side effects of ZEPOSIA. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

INDICATIONS

Multiple Sclerosis (MS): ZEPOSIA® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
Ulcerative Colitis (UC): ZEPOSIA is a prescription medicine used to treat moderately to severely active ulcerative colitis (UC) in adults.

It is not known if ZEPOSIA is safe and effective in children.

Please see full Prescribing Information, including Medication Guide.

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