What to expect

There are a few initial steps to get started with ZEPOSIA. Learn more by watching the video below or scroll down to read on.

1

You and your doctor complete the
Start Form

You and your healthcare provider will work together to fill out and submit a ZEPOSIA Start Form, which acts as your prescription.

Download a Start Form

  • Icon of a nurse

    Once your Start Form is received, you’ll get a call from your UC Nurse Navigator who will:

    • Introduce him or herself as your dedicated ZEPOSIA
      nurse contact
    • Let you know what to expect and any next steps
    • Answer any questions you may have
    • Provide support and answer any questions regarding
      financial assistance and insurance

If you haven't heard from your Nurse Navigator, touch base with your healthcare provider to make sure your Start Form was submitted to ZEPOSIA 360 Support.

Being enrolled in the ZEPOSIA 360 Support™ program ensures you're able to access the support you need throughout your entire treatment journey―including a dedicated Nurse Navigator.

2

A few tests to get started

You can start treatment with ZEPOSIA after taking a few routine tests. If you’ve received some of these tests in the last six months, speak to your healthcare provider as they may not need to be repeated.

Your UC Nurse Navigator or healthcare provider will help schedule these routine tests. For eligible patients, they may all be completed with an in-home visit*:

  • Icon of an ecg

    An electrocardiogram
    (ECG)
    —a common test that uses small sensors to monitor your heart and makes sure it's working normally before you start treatment.

  • Icon of a vial

    Blood work—including complete blood count and liver function tests.

  • Icon of an eye

    An eye exam—this isn’t required for everyone, only for people with a history of macular edema or uveitis.

Doctor with  a mask icon

Limit your exposure with home visits*

Your health is a priority, and during the COVID-19 pandemic, you may want to limit in-person contact. Be sure to ask your healthcare provider about getting your initial testing done at home.

Icon with a dollar sign

There may be costs associated with some of the routine medical tests, but depending on where these tests take place, eligible patients may qualify for reimbursement or incur no costs at all.
You can learn more about costs based on your insurance here.

3

The ZEPOSIA Starter Kit

ZEPOSIA starter kit for patients with ulcerative colitis ZEPOSIA starter kit for patients with ulcerative colitis

Once you’ve been approved by your healthcare provider to begin treatment, you’ll receive the ZEPOSIA Starter Kit. It will either be provided to you by your healthcare provider or delivered directly to your home.

The ZEPOSIA Starter Kit includes medication for the first 37 days of treatment and has two parts:

1

A 7-day Starter Pack, which increases your dosage gradually. Each capsule is labeled by day and color-coded by dosage size. You’ll take one capsule each day.

  • Days 1-4: Capsule is light gray (0.23 mg)
  • Days 5-7: Capsule is half light gray and half orange in color (0.46 mg)

2

A 30-day supply, which you’ll begin taking on day 8 (after completing the 7-day Starter Pack). These orange capsules are the regular daily dosage (0.92 mg) of ZEPOSIA.

4

Keep taking ZEPOSIA—delivered directly to you

Specialty pharmacies focus on distributing medicines for chronic conditions. While all specialty pharmacies will deliver your medicine directly to you, some may even allow you to pick it up. Contact your specialty pharmacy to find out the options that it offers.
  • Getting ZEPOSIA pill icon
    • The specialty pharmacy will call you each month to schedule delivery
    • They may offer refill reminders to help keep you on track with treatment

If you have private or commercial insurance and are experiencing delays or issues with coverage, the ZEPOSIA Bridge Program may be able to provide ZEPOSIA to you for free, as needed, until these issues are resolved (for up to 24 months).

*

Home visits for initial routine medical tests are not available to people enrolled in Medicare, Medicaid, or other federal or state healthcare programs, or to people living in Rhode Island.

Depending on insurance coverage, eligible patients may receive a medical assessment benefit offer for out-of-pocket costs for the initial blood tests, ECG screening, and eye exam, where the full cost is not covered by patients’ insurance. Maximum savings limit applies; patient out-of-pocket expenses may vary. This program is not health insurance. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Please click here for Program Terms, Conditions, and Eligibility Criteria.

To receive a free Bridge Supply of ZEPOSIA, you must have an on-label diagnosis and be denied or experiencing a delay in obtaining coverage under your private or commercial insurance for ZEPOSIA. Federal, state, or similar insurance plans are not eligible for Bridge. Once ZEPOSIA is approved by your commercial insurance plan, you will no longer be eligible for the Bridge Program. The Bridge Program is available where not prohibited by state or local law.

OTHER AREAS TO EXPLORE:

How do you
take ZEPOSIA?

See how ZEPOSIA should be taken and get helpful reminders.

Learn more

A co-pay offer to help save§

Eligible patients can receive a co-pay savings offer to help with the monthly cost of treatment.

Sign up now

§Program terms and eligibility criteria apply.

Important Safety Information

Collapse

Do not take ZEPOSIA if you:

  • have had a heart attack, chest pain (unstable angina), stroke or mini-stroke (transient ischemic attack or TIA), or certain types of heart failure in the last 6 months
  • have or have had a history of certain types of an irregular or abnormal heartbeat (arrhythmia) that is not corrected by a pacemaker
  • have untreated, severe breathing problems during your sleep (sleep apnea)
  • take certain medicines called monoamine oxidase (MAO) inhibitors

Talk to your healthcare provider before taking ZEPOSIA if you have any of these conditions or do not know if you have any of these conditions.

ZEPOSIA may cause serious side effects, including:

  • Infections. ZEPOSIA can increase your risk of serious infections that can be life-threatening and cause death. ZEPOSIA lowers the number of white blood cells (lymphocytes) in your blood. This will usually go back to normal within 3 months of stopping treatment. Your healthcare provider may do a blood test of your white blood cells before you start taking ZEPOSIA.

    Call your healthcare provider right away if you have any of these symptoms of an infection during treatment with ZEPOSIA and for 3 months after your last dose of ZEPOSIA:

    • fever
    • feeling very tired
    • flu-like symptoms
    • cough
    • painful and frequent urination (signs of a urinary tract infection)
    • rash
    • headache with fever, neck stiffness, sensitivity to light, nausea, or confusion (these may be symptoms of meningitis, an infection of the lining around your brain and spine)

    Your healthcare provider may delay starting or may stop your ZEPOSIA treatment if you have an infection.

  • Slow heart rate (also known as bradyarrhythmia) when you start taking ZEPOSIA. ZEPOSIA may cause your heart rate to temporarily slow down, especially during the first 8 days. You will have a test to check the electrical activity of your heart called an electrocardiogram (ECG) before you take your first dose of ZEPOSIA.

    Call your healthcare provider if you experience the following symptoms of slow heart rate:

    • dizziness
    • lightheadedness
    • feeling like your heart is beating slowly or skipping beats
    • shortness of breath
    • confusion
    • chest pain
    • tiredness

    Follow directions from your healthcare provider when starting ZEPOSIA and when you miss a dose.

Continue reading for additional possible serious side effects of ZEPOSIA.

Before taking ZEPOSIA, tell your healthcare provider about all of your medical conditions, including if you:

  • have a fever or infection, or are unable to fight infections due to a disease, or take or have taken medicines that lower your immune system
  • received a vaccine in the past 30 days or are scheduled to receive a vaccine. ZEPOSIA may cause vaccines to be less effective
  • before you start ZEPOSIA, your healthcare provider may give you a chickenpox (Varicella Zoster Virus) vaccine if you have not had one before
  • have had chickenpox or have received the vaccine for chickenpox. Your healthcare provider may do a blood test for the chickenpox virus. You may need to get the full course of the vaccine and wait 1 month before taking ZEPOSIA
  • have a slow heart rate
  • have an irregular or abnormal heartbeat (arrhythmia)
  • have a history of stroke
  • have or have had heart problems, including a heart attack or chest pain
  • have high blood pressure
  • have liver problems
  • have breathing problems, including during your sleep
  • have eye problems, especially an inflammation of the eye called uveitis
  • have diabetes
  • are or plan to become pregnant or if you become pregnant within 3 months after you stop taking ZEPOSIA. ZEPOSIA may harm your unborn baby. If you are a female who can become pregnant, talk to your healthcare provider about what birth control method is right for you during your treatment with ZEPOSIA and for 3 months after you stop taking ZEPOSIA
  • are breastfeeding or plan to breastfeed. It is not known if ZEPOSIA passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take ZEPOSIA.

Tell your healthcare provider about all the medicines you take or have recently taken, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using ZEPOSIA with other medicines can cause serious side effects. Especially tell your healthcare provider if you take or have taken:

  • medicines that affect your immune system, such as alemtuzumab
  • medicines to control your heart rhythm (antiarrhythmics), or heartbeat
  • CYP2C8 inducers such as rifampin
  • CYP2C8 inhibitors such as gemfibrozil (medicine to treat high fat in your blood)
  • opioids (pain medicine), medicines to treat depression, and medicines to treat Parkinson’s disease
  • medicines to control your heart rate and blood pressure (beta blocker medicines and calcium channel blocker medicines)

You should not receive live vaccines during treatment with ZEPOSIA, for at least 1 month before taking ZEPOSIA and for 3 months after you stop taking ZEPOSIA. Vaccines may not work as well when given during treatment with ZEPOSIA.

ZEPOSIA can cause serious side effects, including:

  • liver problems. Your healthcare provider will do blood tests to check your liver before you start taking ZEPOSIA. Call your healthcare provider right away if you have any of the following symptoms:
    • unexplained nausea
    • vomiting
    • stomach area (abdominal) pain
    • tiredness
    • loss of appetite
    • yellowing of the whites of your eyes or skin
    • dark colored urine
  • increased blood pressure. Your healthcare provider should check your blood pressure during treatment with ZEPOSIA. A sudden, severe increase in blood pressure (hypertensive crisis) can happen when you eat certain foods that contain high levels of tyramine.
  • breathing problems. Some people who take ZEPOSIA have shortness of breath. Call your healthcare provider right away if you have new or worsening breathing problems.
  • a problem with your vision called macular edema. Your risk of macular edema is higher if you have diabetes or have had an inflammation of your eye called uveitis. Your healthcare provider should test your vision before you start taking ZEPOSIA if you are at higher risk for macular edema or any time you notice vision changes during treatment with ZEPOSIA. Call your healthcare provider right away if you have any of the following symptoms:
    • blurriness or shadows in the center of your vision
    • sensitivity to light
    • a blind spot in the center of your vision
    • unusually colored vision
  • swelling and narrowing of the blood vessels in your brain. Posterior Reversible Encephalopathy Syndrome (PRES) is a rare condition that has happened with ZEPOSIA and with drugs in the same class. Symptoms of PRES usually get better when you stop taking ZEPOSIA. If left untreated, it may lead to stroke. Your healthcare provider will do a test if you have any symptoms of PRES. Call your healthcare provider right away if you have any of the following symptoms:
    • sudden severe headache
    • sudden confusion
    • sudden loss of vision or other changes in your vision
    • seizure
  • severe worsening of multiple sclerosis (MS) after stopping ZEPOSIA. When ZEPOSIA is stopped, symptoms of MS may return and become worse compared to before or during treatment. Always talk to your healthcare provider before you stop taking ZEPOSIA for any reason. Tell your healthcare provider if you have worsening symptoms of MS after stopping ZEPOSIA.

The most common side effects of ZEPOSIA can include:

  • upper respiratory tract infections
  • elevated liver enzymes
  • low blood pressure when you stand up (orthostatic hypotension)
  • painful and frequent urination (signs of urinary tract infection)
  • back pain
  • high blood pressure
  • headache

These are not all of the possible side effects of ZEPOSIA. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 1-800-FDA-1088.

INDICATIONS

Multiple Sclerosis (MS): ZEPOSIA® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Ulcerative Colitis (UC): ZEPOSIA is a prescription medicine used to treat moderately to severely active ulcerative colitis (UC) in adults.

It is not known if ZEPOSIA is safe and effective in children.

Please see full Prescribing Information and Medication Guide.

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Important Safety Information

Expand

Do not take ZEPOSIA if you:

  • have had a heart attack, chest pain (unstable angina), stroke or mini-stroke (transient ischemic attack or TIA), or certain types of heart failure in the last 6 months
  • have or have had a history of certain types of an irregular or abnormal heartbeat (arrhythmia) that is not corrected by a pacemaker
  • have untreated, severe breathing problems during your sleep (sleep apnea)
  • take certain medicines called monoamine oxidase (MAO) inhibitors

Talk to your healthcare provider before taking ZEPOSIA if you have any of these conditions or do not know if you have any of these conditions.

ZEPOSIA may cause serious side effects, including:

  • Infections. ZEPOSIA can increase your risk of serious infections that can be life-threatening and cause death. ZEPOSIA lowers the number of white blood cells (lymphocytes) in your blood. This will usually go back to normal within 3 months of stopping treatment. Your healthcare provider may do a blood test of your white blood cells before you start taking ZEPOSIA.

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