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1-833-ZEPOSIA

ZEPOSIA is a once-daily pill for adults with moderate to severe ulcerative colitis (UC).

Take as directed by your doctor if certain liver problems exist.

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ZEPOSIA is a once-daily pill for adults with moderate to severe ulcerative colitis (UC).

Take as directed by your doctor if certain liver problems exist.

ZEPOSIA 360 Support™

The ZEPOSIA 360 Support™ program has materials and resources designed to help you get the support you need, whether you’re considering ZEPOSIA or are already getting started with treatment.

Sign up for 360 Support

Which best describes you?

Let us know where you are in your treatment journey so we can provide support that works for you.

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I’m considering ZEPOSIA

ZEPOSIA 360 Support has information that can help you find out if ZEPOSIA may be right for you.

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We’ll keep you updated and informed

By signing up for ZEPOSIA 360 Support communications, you'll receive the latest information sent directly to you, including:

  • Information about ZEPOSIA
  • A guide for talking to your UC healthcare team
  • Stories from real people taking ZEPOSIA
  • A brochure with more information mailed directly to you
  • Helpful alerts sent to your phone (optional)
Sign up for 360 Support
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I’m getting started or currently taking ZEPOSIA

When you begin treatment with ZEPOSIA, you'll have support available to you every step of the way. A dedicated Support Coordinator can help determine your coverage for ZEPOSIA, what your out-of-pocket costs may be, and other financial options.

ZEPOSIA® 360 Support - support coordinator icon

Connecting with a Support Coordinator

Once you’re prescribed ZEPOSIA, a Support Coordinator will contact you to welcome you to the program and guide you through the support offerings. If you haven't heard from a Support Coordinator, reach out to your healthcare team to ensure that your Start Form (your ZEPOSIA prescription) was submitted to ZEPOSIA 360 Support.

Our Support Coordinators can:

  • Help navigate your insurance benefits*
  • Assist you in exploring available support and savings options
  • Arrange for eligible, commercially insured patients to get ZEPOSIA in the event of delays or issues with insurance coverage
  • Assist eligible, commercially insured patients with scheduling the routine tests needed to start ZEPOSIA

Additional support team members are also available to answer questions about ZEPOSIA and provide helpful resources.

1-833-ZEPOSIA (1-833-937-6742), Monday to Friday, 8 AM to 8 PM ET.

  • The accurate completion of reimbursement- or coverage-related documentation is the responsibility of the healthcare provider and patient. Bristol Myers Squibb and its agents make no guarantee regarding reimbursement for any service or item.
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Ways to save on treatment costs

There are also many ways to save on treatment costs, including:

  • A co-pay offer† that helps those who are eligible and commercially insured pay as little as $0 a month for ZEPOSIA
  • Reimbursement for medical costs associated with appointments or routine tests before starting ZEPOSIA, for eligible, commercially insured patients
  • The ZEPOSIA Bridge Program‡ may provide help for eligible, commercially insured patients who are experiencing a delay in obtaining coverage or have been denied coverage
  • If you have difficulty affording your medication, our Support Coordinators can help you identify options that may be available to you
  • Additional eligibility requirements and terms and conditions apply. Please see Combined Co-pay Program (Drug and Medical Benefit) Terms and Conditions.
  • Additional eligibility requirements and terms and conditions apply. Please see ZEPOSIA Bridge Program Terms and Conditions.
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We’ll keep you updated and informed

As a part of ZEPOSIA 360 Support communications, you’ll receive the latest information sent directly to you, including:

  • Information about ZEPOSIA
  • Tips for starting and staying on treatment
  • Ways to live a healthy lifestyle that can have an impact on UC
  • Links to helpful resources
  • A brochure for starting ZEPOSIA mailed directly to you
  • Helpful alerts sent to your phone (optional)
Sign up for 360 Support
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An app to help you get started and stay on track

The Redi.Health for ZEPOSIA app is a tool that can help support you on your UC journey. It includes medication tracking, UC-friendly recipes, information on ZEPOSIA, and more.

Get started by downloading the Redi.Health app from your mobile device and entering code ZEPOSIA.

Download on Apple Store button Download on Google Play button

Rather use the online version? Click here to sign up and get started.

Looking for additional helpful resources?

Access information about UC and downloadable materials for ZEPOSIA, or visit online UC organizations.

Get helpful resources

Are you starting or taking ZEPOSIA?

Sign up for ZEPOSIA 360 Support communications to receive resources, information, and support for starting and staying on treatment.

Sign up now

IMPORTANT SAFETY INFORMATION

Do not take ZEPOSIA if you:

  • have had a heart attack, chest pain (unstable angina), stroke or mini-stroke (transient ischemic attack or TIA), or certain types of heart failure in the last 6 months
  • have or have had a history of certain types of an irregular or abnormal heartbeat (arrhythmia) that is not corrected by a pacemaker
  • have untreated, severe breathing problems during your sleep (sleep apnea)
  • take certain medicines called monoamine oxidase (MAO) inhibitors (such as selegiline, phenelzine, linezolid)

Talk to your healthcare provider before taking ZEPOSIA if you have any of these conditions or do not know if you have any of these conditions.

ZEPOSIA may cause serious side effects, including:

  • Infections. ZEPOSIA can increase your risk of serious infections that can be life-threatening and cause death. ZEPOSIA lowers the number of white blood cells (lymphocytes) in your blood. This will usually go back to normal within 3 months of stopping treatment. Your healthcare provider may do a blood test of your white blood cells before you start taking ZEPOSIA.

    Call your healthcare provider right away if you have any of these symptoms of an infection during treatment with ZEPOSIA and for 3 months after your last dose of ZEPOSIA:

    • fever
    • feeling very tired
    • flu-like symptoms
    • cough
    • painful and frequent urination (signs of a urinary tract infection)
    • rash
    • headache with fever, neck stiffness, sensitivity to light, nausea, or confusion (these may be symptoms of meningitis, an infection of the lining around your brain and spine)

    Your healthcare provider may delay starting or may stop your ZEPOSIA treatment if you have an infection.

  • Progressive multifocal leukoencephalopathy (PML). ZEPOSIA can increase your risk for PML, which is a rare brain infection that usually leads to death or severe disability. If PML happens, it usually happens in people with weakened immune systems but has happened in people who do not have weakened immune systems. Symptoms of PML get worse over days to weeks. Call your doctor right away if you have any new or worsening symptoms of PML that have lasted several days, including: weakness on one (1) side of your body, changes in your vision, changes in your thinking or memory, confusion, changes in your personality, loss of coordination in your arms or legs, decreased strength, and/or problems with balance.
  • Slow heart rate (also known as bradyarrhythmia) when you start taking ZEPOSIA. ZEPOSIA may cause your heart rate to temporarily slow down, especially during the first 8 days. You will have a test to check the electrical activity of your heart called an electrocardiogram (ECG) before you take your first dose of ZEPOSIA.

    Call your healthcare provider if you experience the following symptoms of slow heart rate:

    • dizziness
    • lightheadedness
    • feeling like your heart is beating slowly or skipping beats
    • shortness of breath
    • confusion
    • chest pain
    • tiredness

Follow directions from your healthcare provider when starting ZEPOSIA and when you miss a dose.

Continue reading for additional possible serious side effects of ZEPOSIA.

Before taking ZEPOSIA, tell your healthcare provider about all of your medical conditions, including if you:

  • have a fever or infection, or are unable to fight infections due to a disease, or take or have taken medicines that lower your immune system
  • received a vaccine in the past 30 days or are scheduled to receive a vaccine. ZEPOSIA may cause vaccines to be less effective
  • before you start ZEPOSIA, your healthcare provider may give you a chickenpox (Varicella Zoster Virus) vaccine if you have not had one before
  • have had chickenpox or have received the vaccine for chickenpox. Your healthcare provider may do a blood test for the chickenpox virus. You may need to get the full course of the vaccine and wait 1 month before taking ZEPOSIA
  • have a slow heart rate
  • have an irregular or abnormal heartbeat (arrhythmia)
  • have a history of stroke
  • have or have had heart problems, including a heart attack or chest pain
  • have high blood pressure
  • have liver problems
  • have breathing problems, including during your sleep
  • have eye problems, especially an inflammation of the eye called uveitis
  • have diabetes
  • are or plan to become pregnant or if you become pregnant within 3 months after you stop taking ZEPOSIA. ZEPOSIA may harm your unborn baby. If you are a female who can become pregnant, talk to your healthcare provider about what birth control method is right for you during your treatment with ZEPOSIA and for 3 months after you stop taking ZEPOSIA. If you become pregnant while taking ZEPOSIA for MS, tell your healthcare provider right away and enroll in the ZEPOSIA Pregnancy Registry by calling 1-877-301-9314 or visiting www.zeposiapregnancyregistry.com
  • are breastfeeding or plan to breastfeed. It is not known if ZEPOSIA passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take ZEPOSIA

Tell your healthcare provider about all the medicines you take or have recently taken, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using ZEPOSIA with other medicines can cause serious side effects. Especially tell your healthcare provider if you take or have taken:

  • medicines that affect your immune system, such as alemtuzumab
  • medicines to control your heart rhythm (antiarrhythmics), or heartbeat
  • CYP2C8 inducers such as rifampin
  • CYP2C8 inhibitors such as gemfibrozil (medicine to treat high fat in your blood)
  • opioids (pain medicine), medicines to treat depression, and medicines to treat Parkinson’s disease
  • medicines to control your heart rate and blood pressure (beta blocker medicines and calcium channel blocker medicines)

You should not receive live vaccines during treatment with ZEPOSIA, for at least 1 month before taking ZEPOSIA and for 3 months after you stop taking ZEPOSIA. Vaccines may not work as well when given during treatment with ZEPOSIA.

ZEPOSIA can cause serious side effects, including:

  • liver problems. Your healthcare provider will do blood tests to check your liver before you start taking ZEPOSIA. Call your healthcare provider right away if you have any of the following symptoms:
    • unexplained nausea
    • vomiting
    • stomach area (abdominal) pain
    • tiredness
    • loss of appetite
    • yellowing of the whites of your eyes or skin
    • dark colored urine
  • increased blood pressure. Your healthcare provider should check your blood pressure during treatment with ZEPOSIA. A sudden, severe increase in blood pressure (hypertensive crisis) can happen when you eat certain foods that contain high levels of tyramine.
  • breathing problems. Some people who take ZEPOSIA have shortness of breath. Call your healthcare provider right away if you have new or worsening breathing problems.
  • a problem with your vision called macular edema. Your risk of macular edema is higher if you have diabetes or have had an inflammation of your eye called uveitis. Your healthcare provider should test your vision before you start taking ZEPOSIA if you are at higher risk for macular edema or any time you notice vision changes during treatment with ZEPOSIA. Call your healthcare provider right away if you have any of the following symptoms:
    • blurriness or shadows in the center of your vision
    • sensitivity to light
    • a blind spot in the center of your vision
    • unusually colored vision
  • swelling and narrowing of the blood vessels in your brain. Posterior Reversible Encephalopathy Syndrome (PRES) is a rare condition that has happened with ZEPOSIA and with drugs in the same class. Symptoms of PRES usually get better when you stop taking ZEPOSIA. If left untreated, it may lead to stroke. Your healthcare provider will do a test if you have any symptoms of PRES. Call your healthcare provider right away if you have any of the following symptoms:
    • sudden severe headache
    • sudden confusion
    • sudden loss of vision or other changes in your vision
    • seizure
  • severe worsening of multiple sclerosis (MS) after stopping ZEPOSIA. When ZEPOSIA is stopped, symptoms of MS may return and become worse compared to before or during treatment. Always talk to your healthcare provider before you stop taking ZEPOSIA for any reason. Tell your healthcare provider if you have worsening symptoms of MS after stopping ZEPOSIA.

The most common side effects of ZEPOSIA can include:

  • upper respiratory tract infections
  • elevated liver enzymes
  • low blood pressure when you stand up (orthostatic hypotension)
  • painful and frequent urination (signs of urinary tract infection)
  • back pain
  • high blood pressure
  • headache

These are not all of the possible side effects of ZEPOSIA. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

INDICATIONS

Multiple Sclerosis (MS): ZEPOSIA® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
Ulcerative Colitis (UC): ZEPOSIA is a prescription medicine used to treat moderately to severely active ulcerative colitis (UC) in adults.

It is not known if ZEPOSIA is safe and effective in children.

Please see full Prescribing Information, including Medication Guide.

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2084-US-2301034 10/23

2084-US-2301365 01/24

2084-US-2301365 01/24