I remember for years just feeling up and down, just not in control ... I needed a change.”

—Amy

Mother, educator, and learner-at-heart

Read Amy’s story +
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Though Amy has maintained remission* from her UC symptoms with ZEPOSIA, it has been a long journey of trial and error and self-advocacy to reach this point.

Amy was first diagnosed with UC in 2001 when her symptoms got so bad that she had to finish her college semester from home. Her GI prescribed two different medications, yet Amy could not find adequate symptom relief. She still experienced stomach pain, fatigue, and blood in her stool.

On and off steroids for years, Amy lived in a constant state of worry and questioning. Amy decided to seek out a new doctor, and she found one who treated her like a partner. Her new doctor told her that she had other options; he gave her a newfound confidence.

With her new doctor, Amy tried a variety of medications: pills, injections, infusions, suppositories. And finally, her doctor recommended ZEPOSIA.

Within weeks, Amy was feeling better. Her symptoms went away—and stayed away.

Able to maintain remission, Amy is now sharing her story, in hopes of helping others with UC. Though it was a long journey to symptom relief, by participating in organizations and support programs, Amy can use her experience to help others.

*

Individual results may vary. Click here to learn more about results from the clinical studies.

Since starting ZEPOSIA, I have much more confidence in my treatment plan. It’s nice getting to do things on my time again.”

—Trey

Performer, gamer, fitness enthusiast

Read Trey’s story +
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When Trey’s UC symptoms appeared, they interrupted his active social life and various hobbies. His journey with ZEPOSIA and ZEPOSIA 360 SupportTM helped him get back on track to doing the things he loves.

Whether he’s working out, playing video games, or cosplaying at conventions, Trey loves surrounding himself with good people. But when he started experiencing UC symptoms, Trey couldn’t go on drives, hikes, or even short walks without interruption. His doctor prescribed two pills and an enema—but within one year Trey’s symptoms started coming back.

Once Trey and his doctor discussed and he was prescribed ZEPOSIA, a clinician was sent directly to Trey's home to conduct his routine tests. A UC Nurse Navigator from ZEPOSIA 360 Support also helped him get started, directly communicating with his insurance and pharmacy.

Since starting ZEPOSIA, Trey has experienced remission from his symptoms: no more blood in his stool, and his bathroom frequency has returned to normal. With fewer symptoms interrupting his days, Trey can go on hikes again, go to conventions, and drive upstate to see his parents. He’s living life, uninterrupted.

Home visits for initial routine medical tests are not available to people enrolled in Medicare, Medicaid, or other federal or state healthcare programs, or to people living in Rhode Island.

Individual results may vary. Click here to learn more about results from the clinical studies.

Taking a once-daily pill has been great for me. It's easy for me to
remember—it’s the first thing I do in the morning.”

—Tim

Business owner, cyclist, and dog dad

Read Tim’s story +
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It took years—and trying multiple treatments—before Tim could find lasting UC symptom relief, but he never gave up. After having open conversations with his doctor about his symptoms and the toll they were taking on his everyday life, Tim was prescribed ZEPOSIA—a once-daily pill that helped him reach remission.§

For Tim, a long-distance cyclist and business owner, the sudden appearance of UC was a shock. His professional life and hobbies were interrupted by severe symptoms of UC, and it was the first time he’d experienced a major health event.

Despite trying multiple medications, Tim struggled to find consistent relief. He even tried an injectable treatment, which reduced his symptoms at first—but they returned.

With his pain and frequent UC symptoms, Tim was unable to perform his job duties or see his friends and family. This years-long struggle took an emotional toll on him: he didn’t know when, or if, he’d ever feel better.

When Tim started seeing a new gastroenterologist, they discussed his treatment history, the symptoms he was having, and how they were affecting his life. That’s when Tim’s doctor told him about ZEPOSIA, a once-daily pill that worked differently than the other medications Tim had tried.

Since starting ZEPOSIA, Tim has achieved remission and has not experienced any flares. Without his debilitating symptoms, Tim has been able to return to his business and enjoy time with his friends and family again. He has even returned to his favorite hobby—long-distance cycling.

Watch a video to learn more about Tim’s story and how he and his doctor worked together to help him achieve his treatment goals.

§

Individual results may vary. Click here to learn more about results from the clinical studies.

Individual results may vary. These are real patient stories and the participants were compensated for their time.

Other areas to explore:

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Hear stories from real people
with UC and see
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their everyday lives.

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Depending on insurance coverage and where the full cost is not covered by patients’ insurance, eligible patients may receive a prescription benefit offer for out‐of‐pocket drug costs and pay as little as $0 per prescription, as well as a medical assessment benefit offer for out‐of‐pocket costs for the initial blood tests, ECG screening, and eye exam. Maximum savings limit applies; patient out-of‐pocket expenses may vary. This program is not health insurance. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Click here for Program Terms, Conditions, and Eligibility Criteria.

Important Safety Information

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Do not take ZEPOSIA if you:

  • have had a heart attack, chest pain (unstable angina), stroke or mini-stroke (transient ischemic attack or TIA), or certain types of heart failure in the last 6 months
  • have or have had a history of certain types of an irregular or abnormal heartbeat (arrhythmia) that is not corrected by a pacemaker
  • have untreated, severe breathing problems during your sleep (sleep apnea)
  • take certain medicines called monoamine oxidase (MAO) inhibitors (such as selegiline, phenelzine, linezolid)

Talk to your healthcare provider before taking ZEPOSIA if you have any of these conditions or do not know if you have any of these conditions.

ZEPOSIA may cause serious side effects, including:

  • Infections. ZEPOSIA can increase your risk of serious infections that can be life-threatening and cause death. ZEPOSIA lowers the number of white blood cells (lymphocytes) in your blood. This will usually go back to normal within 3 months of stopping treatment. Your healthcare provider may do a blood test of your white blood cells before you start taking ZEPOSIA.

    Call your healthcare provider right away if you have any of these symptoms of an infection during treatment with ZEPOSIA and for 3 months after your last dose of ZEPOSIA:

    • fever
    • feeling very tired
    • flu-like symptoms
    • cough
    • painful and frequent urination (signs of a urinary tract infection)
    • rash
    • headache with fever, neck stiffness, sensitivity to light, nausea, or confusion (these may be symptoms of meningitis, an infection of the lining around your brain and spine)

    Your healthcare provider may delay starting or may stop your ZEPOSIA treatment if you have an infection.

  • Progressive multifocal leukoencephalopathy (PML). ZEPOSIA can increase your risk for PML, which is a rare brain infection that usually leads to death or severe disability. If PML happens, it usually happens in people with weakened immune systems but has happened in people who do not have weakened immune systems. Symptoms of PML get worse over days to weeks. Call your doctor right away if you have any new or worsening symptoms of PML that have lasted several days, including: weakness on one (1) side of your body, changes in your vision, changes in your thinking or memory, confusion, changes in your personality, loss of coordination in your arms or legs, decreased strength, and/or problems with balance.

  • Slow heart rate (also known as bradyarrhythmia) when you start taking ZEPOSIA. ZEPOSIA may cause your heart rate to temporarily slow down, especially during the first 8 days. You will have a test to check the electrical activity of your heart called an electrocardiogram (ECG) before you take your first dose of ZEPOSIA.

    Call your healthcare provider if you experience the following symptoms of slow heart rate:

    • dizziness
    • lightheadedness
    • feeling like your heart is beating slowly or skipping beats
    • shortness of breath
    • confusion
    • chest pain
    • tiredness

Follow directions from your healthcare provider when starting ZEPOSIA and when you miss a dose.

Continue reading for additional possible serious side effects of ZEPOSIA.

Before taking ZEPOSIA, tell your healthcare provider about all of your medical conditions, including if you:

  • have a fever or infection, or are unable to fight infections due to a disease, or take or have taken medicines that lower your immune system
  • received a vaccine in the past 30 days or are scheduled to receive a vaccine. ZEPOSIA may cause vaccines to be less effective
  • before you start ZEPOSIA, your healthcare provider may give you a chickenpox (Varicella Zoster Virus) vaccine if you have not had one before
  • have had chickenpox or have received the vaccine for chickenpox. Your healthcare provider may do a blood test for the chickenpox virus. You may need to get the full course of the vaccine and wait 1 month before taking ZEPOSIA
  • have a slow heart rate
  • have an irregular or abnormal heartbeat (arrhythmia)
  • have a history of stroke
  • have or have had heart problems, including a heart attack or chest pain
  • have high blood pressure
  • have liver problems
  • have breathing problems, including during your sleep
  • have eye problems, especially an inflammation of the eye called uveitis
  • have diabetes
  • are or plan to become pregnant or if you become pregnant within
    3 months after you stop taking ZEPOSIA. ZEPOSIA may harm your unborn baby. If you are a female who can become pregnant, talk to your healthcare provider about what birth control method is right for you during your treatment with ZEPOSIA and for 3 months after you stop taking ZEPOSIA. If you become pregnant while taking ZEPOSIA for MS, tell your healthcare provider right away and enroll in the ZEPOSIA Pregnancy Registry by calling 1-877-301-9314 or visiting www.zeposiapregnancyregistry.com
  • are breastfeeding or plan to breastfeed. It is not known if ZEPOSIA passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take ZEPOSIA

Tell your healthcare provider about all the medicines you take or have recently taken, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using ZEPOSIA with other medicines can cause serious side effects. Especially tell your healthcare provider if you take or have taken:

  • medicines that affect your immune system, such as alemtuzumab
  • medicines to control your heart rhythm (antiarrhythmics), or heartbeat
  • CYP2C8 inducers such as rifampin
  • CYP2C8 inhibitors such as gemfibrozil (medicine to treat high fat in your blood)
  • opioids (pain medicine), medicines to treat depression, and medicines to treat Parkinson’s disease
  • medicines to control your heart rate and blood pressure (beta blocker medicines and calcium channel blocker medicines)

You should not receive live vaccines during treatment with ZEPOSIA, for at least 1 month before taking ZEPOSIA and for 3 months after you stop taking ZEPOSIA. Vaccines may not work as well when given during treatment with ZEPOSIA.

ZEPOSIA can cause serious side effects, including:

  • liver problems. Your healthcare provider will do blood tests to check your liver before you start taking ZEPOSIA. Call your healthcare provider right away if you have any of the following symptoms:
    • unexplained nausea
    • vomiting
    • stomach area (abdominal) pain
    • tiredness
    • loss of appetite
    • yellowing of the whites of your eyes or skin
    • dark colored urine
  • increased blood pressure. Your healthcare provider should check your blood pressure during treatment with ZEPOSIA. A sudden, severe increase in blood pressure (hypertensive crisis) can happen when you eat certain foods that contain high levels of tyramine.
  • breathing problems. Some people who take ZEPOSIA have shortness of breath. Call your healthcare provider right away if you have new or worsening breathing problems.
  • a problem with your vision called macular edema. Your risk of macular edema is higher if you have diabetes or have had an inflammation of your eye called uveitis. Your healthcare provider should test your vision before you start taking ZEPOSIA if you are at higher risk for macular edema or any time you notice vision changes during treatment with ZEPOSIA. Call your healthcare provider right away if you have any of the following symptoms:
    • blurriness or shadows in the center of your vision
    • sensitivity to light
    • a blind spot in the center of your vision
    • unusually colored vision
  • swelling and narrowing of the blood vessels in your brain. Posterior Reversible Encephalopathy Syndrome (PRES) is a rare condition that has happened with ZEPOSIA and with drugs in the same class. Symptoms of PRES usually get better when you stop taking ZEPOSIA. If left untreated, it may lead to stroke. Your healthcare provider will do a test if you have any symptoms of PRES. Call your healthcare provider right away if you have any of the following symptoms:
    • sudden severe headache
    • sudden confusion
    • sudden loss of vision or other changes in your vision
    • seizure
  • severe worsening of multiple sclerosis (MS) after stopping ZEPOSIA. When ZEPOSIA is stopped, symptoms of MS may return and become worse compared to before or during treatment. Always talk to your healthcare provider before you stop taking ZEPOSIA for any reason. Tell your healthcare provider if you have worsening symptoms of MS after stopping ZEPOSIA.

The most common side effects of ZEPOSIA can include:

  • upper respiratory tract infections
  • elevated liver enzymes
  • low blood pressure when you stand up (orthostatic hypotension)
  • painful and frequent urination (signs of urinary tract infection)
  • back pain
  • high blood pressure
  • headache

These are not all of the possible side effects of ZEPOSIA. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 1-800-FDA-1088.

INDICATIONS

Multiple Sclerosis (MS): ZEPOSIA® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Ulcerative Colitis (UC): ZEPOSIA is a prescription medicine used to treat moderately to severely active ulcerative colitis (UC) in adults.
It is not known if ZEPOSIA is safe and effective in children.

Please see full Prescribing Information, including Medication Guide.

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Important Safety Information

Expand

Do not take ZEPOSIA if you:

  • have had a heart attack, chest pain (unstable angina), stroke or mini-stroke (transient ischemic attack or TIA), or certain types of heart failure in the last 6 months
  • have or have had a history of certain types of an irregular or abnormal heartbeat (arrhythmia) that is not corrected by a pacemaker
  • have untreated, severe breathing problems during your sleep (sleep apnea)
  • take certain medicines called monoamine oxidase (MAO) inhibitors (such as selegiline, phenelzine, linezolid)

Talk to your healthcare provider before taking ZEPOSIA if you have any of these conditions or do not know if you have any of these conditions.

ZEPOSIA may cause serious side effects, including:

  • Infections. ZEPOSIA can increase your risk of serious infections that can be life-threatening and cause death. ZEPOSIA lowers the number of white blood cells (lymphocytes) in your blood. This will usually go back to normal within 3 months of stopping treatment. Your healthcare provider may do a blood test of your white blood cells before you start taking ZEPOSIA.

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