ZEPOSIA (ozanimod) Stories

This website is intended for U.S. residents 18 years of age or older.

Indications

INDICATIONS

ZEPOSIA^® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

It is not known if ZEPOSIA is safe and effective in children.

ZEPOSIA^® (ozanimod) is a prescription medicine used to treat moderately to severely active ulcerative colitis (UC) in adults.

It is not known if ZEPOSIA is safe and effective in children.
U.S. Full Prescribing Information
Medication Guide
En Español
Healthcare Professionals

If you’re considering treatment with ZEPOSIA, it can be helpful to hear from someone who’s been there. These unique stories feature real people who take ZEPOSIA for their relapsing multiple sclerosis (MS).

You can also sign up to become a Patient Ambassador and share your story.

There can be a lot of challenges with having MS, but ZEPOSIA helps me keep moving forward.”

—Deina

MS champion, yogi, and aunt

Read Deina’s story + Close – Read Deina’s story +

It took years of unexplained symptoms for Deina to receive her MS diagnosis, but today she stays active living with MS. She practices equine therapy (a form of therapy on horseback), yoga, and loves to explore her home, Puerto Rico.

Deina’s MS symptoms started in college. She experienced a sharp sensation in her abdomen, tingling, and had trouble walking and with her gait. It was hard to be a student with an undiagnosed condition. Deina confided in her friends and family, but at first they did not believe her.

Being her own self-advocate, Deina went to several doctors, but they were not able to give her the answers she needed. She went to two different neurologists and was finally diagnosed with MS. She was so relieved to have found the answer.

Deina’s neurologist thought she was a good candidate for ZEPOSIA, a once-daily pill for relapsing MS, so they started treatment. Deina likes ZEPOSIA because it’s a once-daily pill that works for her, and she and her neurologist are pleased with her results.

Today, Deina approaches MS as a campéon, which is Spanish for champion. With ZEPOSIA helping her feel confident in managing her multiple sclerosis, she refuses to let MS bring her down.

I like ZEPOSIA because it’s a once-daily pill that works for me. I’m glad my doctor recommended that I start taking it.”

—Sara

Healthcare administrator and mother

Read Sara’s story + Close – Read Sara’s story +

Sara’s diagnosis came as a surprise and left her wondering about her future. Today, she’s a mother of two and works in healthcare.

As Sara was beginning her career, she was driving home from work and realized her vision was blurry. With her mother’s help, they looked for answers.

Sara went to an ophthalmologist first, who referred her to a neurologist. She had a magnetic resonance imaging (MRI) scan, which revealed that she was living with relapsing MS.

To treat Sara’s MS, her neurologist prescribed an injectable medication, which Sara found challenging to take.

Sara took the injectable medicine for a few years. Then she stopped treatment because she and her husband decided to start a family.

After the birth of her two sons, she experienced MS symptoms again, so she went back to her neurologist. Sara’s neurologist recommended ZEPOSIA, a once-daily pill, and she began treatment.

Sara likes ZEPOSIA because it’s a once-daily pill that fits into her lifestyle. Since starting treatment, she looks forward to the future and is excited to see her boys grow up.

Having a dedicated MS Nurse Navigator get me started on ZEPOSIA was so helpful. My Nurse Navigator also checks in on me as needed to see how ZEPOSIA is working for me.”

—Jon

Geologist, traveler, and husband.

Read Jon’s story + Close – Read Jon’s story +

Jon, a geologist, husband, and traveler didn’t let MS stand in the way of pursuing his dreams.

As an undergraduate student of geology, Jon began experiencing MS symptoms that came as a shock. He experienced numbness and pain in his hands and feet, balance problems, and anxiety. He saw a neurologist and was diagnosed with MS.

Despite his diagnosis, Jon graduated and went on to pursue his master’s degree. He even managed to travel to Iceland and explore the geology of the island with his classmates.

After graduation, Jon moved and found a new neurologist. His new neurologist recommended ZEPOSIA, a once-daily pill for relapsing MS—and it’s been working well for him.

Since starting ZEPOSIA, Jon has worked closely with his MS Nurse Navigator, who answers his questions about ZEPOSIA, and helps navigate insurance benefits and financial assistance options. Jon looks forward to their monthly check-ins and is glad to have the support his Nurse Navigator provides.

And despite MS, he’s still pursuing his dreams: he’s become a working geologist, returned to Iceland, and married the woman of his dreams.

I’d heard a lot about ZEPOSIA, so I mentioned it to my doctor, and she decided it was a good choice for me. It’s been over a year now, and it’s working well for me. My doctor is happy with the results.”

—Melissa

Educator, athlete, and optimist
(Individual results may vary.)

Read Melissa’s story + Close – Read Melissa’s story +

As an athlete and educator, Melissa’s always lived an active lifestyle. Shaken by her MS diagnosis, Melissa was nervous about her future. But through the MS community, she’s found passion, connection, and a treatment option that works for her: ZEPOSIA.

Melissa was pursuing her master’s degree, teaching, coaching, and training for her first marathon when one day she noticed numbness in her feet.

When her symptoms started to interrupt her training, she began to seek answers. Melissa was referred to a neurologist. Her magnetic resonance imaging (MRI) scan showed signs of MS, and her neurologist confirmed the diagnosis.

Her MS diagnosis was a shock, and Melissa’s positive attitude faltered. She was worried about her future, even reluctant to tell her friends about her diagnosis. But when she finally did, their positivity and support helped Melissa find something important: a community.

Through a coworker’s recommendation, Melissa signed up to participate in MS bike rides. Through this group, she was connected to her new neurologist, an MS specialist. Melissa’s neurologist told her about ZEPOSIA, a once-daily pill for relapsing MS. Her neurologist thought ZEPOSIA would be a good fit for her, so Melissa began treatment.

Melissa has now been taking ZEPOSIA for a year. She and her neurologist have a strong relationship. They check in monthly and are pleased with her results. With help from ZEPOSIA, exercise, stress management, and a healthy sleep schedule, Melissa has been able to focus on her goals.

She is now an assistant principal at an elementary school and remains highly active in the MS community. She attends events, has become an advocate for those who don’t feel comfortable sharing their MS diagnosis, and has raised over $120,000 with her MS bike ride team to date.

Since starting ZEPOSIA in 2020, I’ve been able to manage my MS, and I haven’t had any new (active) lesions.”

—Omar

Radio host, voiceover artist, and husband
(Individual results may vary.)

Read Omar’s story + Close – Read Omar’s story +

Omar, a radio host in Puerto Rico, maintains a healthy lifestyle after years of living with MS.

As a radio host, Omar relies on his speech, which was the first indicator that something was wrong. His speech was slowing, he felt clumsy, and the left side of his body felt “off.”

These symptoms reminded him of a similar experience in 1997. Omar had an MRI, which revealed that he may have unknowingly been living with relapsing MS for nearly 25 years.

Omar’s neurologist decided to start him on treatment. But after experiencing side effects, Omar sought a second opinion. He met with another neurologist who thought that Omar was a good candidate for ZEPOSIA. He and his neurologist discussed the clinical study results of ZEPOSIA and the possible side effects, and he began treatment.

Omar’s MS Nurse Navigator helped him get started and coordinated with his specialty pharmacy to arrange delivery of his medication to his home. He has also used the ZEPOSIA co-pay savings offer to help cover the cost of his monthly prescription.*

Omar has been taking ZEPOSIA since 2020, and after almost two years of treatment, he hasn’t had any new active lesions.^† He maintains a healthy lifestyle and continues to live well with MS. He’s looking to the future and is grateful for the support of his family and MS healthcare team.

^†Individual results may vary.

When I was diagnosed, I learned a lot about MS very quickly. I also researched and read everything about ZEPOSIA and the 360 Support program, which helped me move forward in my life with MS.”

—Kathleen

World traveler and go-getter

Read Kathleen’s story + Close – Read Kathleen’s story +

Kathleen, a driven professional and frequent traveler, received an MS diagnosis that changed her world as she knew it. But as a “doer,” Kathleen approached her MS like she would any other task. She turned it into Project “Treat Kathleen’s MS” and quickly gathered information about MS and ZEPOSIA.

In 2020, Kathleen woke up with blurry vision. She attributed it to working long hours and lots of screen time. But the blurriness worsened, and she soon lost her peripheral vision.

When a retina specialist thought Kathleen had problems with her optic nerve, she was referred to a neuro-ophthalmologist who specializes in neurological-based vision issues. This doctor confirmed that Kathleen had relapsing MS through magnetic resonance imaging (MRI) scan results.

Kathleen then found a neurologist specializing in MS who provided helpful information so they could make informed decisions together. Kathleen has also learned a lot about MS, including how to cope with emotions—and lifestyle changes that may have an impact on the condition.

After Kathleen’s neurologist told her about ZEPOSIA, a once-daily pill that treats relapsing MS, she researched it and learned all about ZEPOSIA and the 360 Support program. With this knowledge, Kathleen was able to approach MS head on and move forward with her life. Her neurologist started her on ZEPOSIA and Kathleen has not looked back.

ZEPOSIA has worked well for Kathleen. She likes that it’s a once-daily pill that fits into her active lifestyle.

Now, when Kathleen’s MS diagnosis anniversary approaches, she asks herself what the diagnosis meant to her: a chance to find time to reflect, focus on her well-being, and understand what is truly important to her.

Icon of ZEPOSIA (ozanimod) patient ambassador

Become a ZEPOSIA Patient Ambassador

Sharing your story can inspire others and make a big difference. When and how you participate is up to you, but by signing up you can have the opportunity to share your story through videos, events, and more.

You can also sign up by calling 1-844-514-6290 or by sending an
e-mail to lindaw@mypatientstory.com

Other areas to explore:

Save on
treatment costs

Those who are eligible may pay as little as $0 a month for ZEPOSIA with a co-pay savings offer.*
Sign up now
Want more information on ZEPOSIA?

Sign up to receive the latest ZEPOSIA details, stories from real people taking ZEPOSIA, and more from ZEPOSIA 360 Support.™
Get started

*Depending on insurance coverage, eligible patients may receive a prescription benefit offer for out-of-pocket costs for the drug costs and pay as little as $0 per prescription. Maximum savings limit applies; patient out-of-pocket expenses may vary. This program is not health insurance. Offer not valid for patients enrolled in Medicare, Medicaid or other federal or state healthcare programs. Click here for Program Terms, Conditions, and Eligibility Criteria.

Important Safety Information

Collapse

–

Do not take ZEPOSIA if you:

have had a heart attack, chest pain (unstable angina), stroke or mini-stroke (transient ischemic attack or TIA), or certain types of heart failure in the last 6 months
have or have had a history of certain types of an irregular or abnormal heartbeat (arrhythmia) that is not corrected by a pacemaker
have untreated, severe breathing problems during your sleep (sleep apnea)
take certain medicines called monoamine oxidase (MAO) inhibitors (such as selegiline, phenelzine, linezolid)

Talk to your healthcare provider before taking ZEPOSIA if you have any of these conditions or do not know if you have any of these conditions.

ZEPOSIA may cause serious side effects, including:

Infections. ZEPOSIA can increase your risk of serious infections that can be life-threatening and cause death. ZEPOSIA lowers the number of white blood cells (lymphocytes) in your blood. This will usually go back to normal within 3 months of stopping treatment. Your healthcare provider may do a blood test of your white blood cells before you start taking ZEPOSIA.
Call your healthcare provider right away if you have any of these symptoms of an infection during treatment with ZEPOSIA and for 3 months after your last dose of ZEPOSIA:
- fever
- feeling very tired
- flu-like symptoms
- cough
- painful and frequent urination (signs of a urinary tract infection)
- rash
- headache with fever, neck stiffness, sensitivity to light, nausea, or confusion (these may be symptoms of meningitis, an infection of the lining around your brain and spine)
Your healthcare provider may delay starting or may stop your ZEPOSIA treatment if you have an infection.
Progressive multifocal leukoencephalopathy (PML). ZEPOSIA can increase your risk for PML, which is a rare brain infection that usually leads to death or severe disability. If PML happens, it usually happens in people with weakened immune systems but has happened in people who do not have weakened immune systems. Symptoms of PML get worse over days to weeks. Call your doctor right away if you have any new or worsening symptoms of PML that have lasted several days, including: weakness on one (1) side of your body, changes in your vision, changes in your thinking or memory, confusion, changes in your personality, loss of coordination in your arms or legs, decreased strength, and/or problems with balance.
Slow heart rate (also known as bradyarrhythmia) when you start taking ZEPOSIA. ZEPOSIA may cause your heart rate to temporarily slow down, especially during the first 8 days. You will have a test to check the electrical activity of your heart called an electrocardiogram (ECG) before you take your first dose of ZEPOSIA.
Call your healthcare provider if you experience the following symptoms of slow heart rate:
- dizziness
- lightheadedness
- feeling like your heart is beating slowly or skipping beats
- shortness of breath
- confusion
- chest pain
- tiredness

Follow directions from your healthcare provider when starting ZEPOSIA and when you miss a dose.

Continue reading for additional possible serious side effects of ZEPOSIA.

Before taking ZEPOSIA, tell your healthcare provider about all of your medical conditions, including if you:

have a fever or infection, or are unable to fight infections due to a disease, or take or have taken medicines that lower your immune system
received a vaccine in the past 30 days or are scheduled to receive a vaccine. ZEPOSIA may cause vaccines to be less effective
before you start ZEPOSIA, your healthcare provider may give you a chickenpox (Varicella Zoster Virus) vaccine if you have not had one before
have had chickenpox or have received the vaccine for chickenpox. Your healthcare provider may do a blood test for the chickenpox virus. You may need to get the full course of the vaccine and wait 1 month before taking ZEPOSIA
have a slow heart rate
have an irregular or abnormal heartbeat (arrhythmia)
have a history of stroke
have or have had heart problems, including a heart attack or chest pain
have high blood pressure
have liver problems
have breathing problems, including during your sleep
have eye problems, especially an inflammation of the eye called uveitis
have diabetes
are or plan to become pregnant or if you become pregnant within 3 months after you stop taking ZEPOSIA. ZEPOSIA may harm your unborn baby. If you are a female who can become pregnant, talk to your healthcare provider about what birth control method is right for you during your treatment with ZEPOSIA and for 3 months after you stop taking ZEPOSIA. If you become pregnant while taking ZEPOSIA for MS, tell your healthcare provider right away and enroll in the ZEPOSIA Pregnancy Registry by calling 1-877-301-9314 or visiting www.zeposiapregnancyregistry.com
are breastfeeding or plan to breastfeed. It is not known if ZEPOSIA passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take ZEPOSIA

Tell your healthcare provider about all the medicines you take or have recently taken, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using ZEPOSIA with other medicines can cause serious side effects. Especially tell your healthcare provider if you take or have taken:

medicines that affect your immune system, such as alemtuzumab
medicines to control your heart rhythm (antiarrhythmics), or heartbeat
CYP2C8 inducers such as rifampin
CYP2C8 inhibitors such as gemfibrozil (medicine to treat high fat in your blood)
opioids (pain medicine), medicines to treat depression, and medicines to treat Parkinson’s disease
medicines to control your heart rate and blood pressure (beta blocker medicines and calcium channel blocker medicines)

You should not receive live vaccines during treatment with ZEPOSIA, for at least 1 month before taking ZEPOSIA and for 3 months after you stop taking ZEPOSIA. Vaccines may not work as well when given during treatment with ZEPOSIA.

ZEPOSIA can cause serious side effects, including:

liver problems. Your healthcare provider will do blood tests to check your liver before you start taking ZEPOSIA. Call your healthcare provider right away if you have any of the following symptoms:
- unexplained nausea
- vomiting
- stomach area (abdominal) pain
- tiredness
- loss of appetite
- yellowing of the whites of your eyes or skin
- dark colored urine
increased blood pressure. Your healthcare provider should check your blood pressure during treatment with ZEPOSIA. A sudden, severe increase in blood pressure (hypertensive crisis) can happen when you eat certain foods that contain high levels of tyramine.
breathing problems. Some people who take ZEPOSIA have shortness of breath. Call your healthcare provider right away if you have new or worsening breathing problems.
a problem with your vision called macular edema. Your risk of macular edema is higher if you have diabetes or have had an inflammation of your eye called uveitis. Your healthcare provider should test your vision before you start taking ZEPOSIA if you are at higher risk for macular edema or any time you notice vision changes during treatment with ZEPOSIA. Call your healthcare provider right away if you have any of the following symptoms:
- blurriness or shadows in the center of your vision
- sensitivity to light
- a blind spot in the center of your vision
- unusually colored vision
swelling and narrowing of the blood vessels in your brain. Posterior Reversible Encephalopathy Syndrome (PRES) is a rare condition that has happened with ZEPOSIA and with drugs in the same class. Symptoms of PRES usually get better when you stop taking ZEPOSIA. If left untreated, it may lead to stroke. Your healthcare provider will do a test if you have any symptoms of PRES. Call your healthcare provider right away if you have any of the following symptoms:
- sudden severe headache
- sudden confusion
- sudden loss of vision or other changes in your vision
- seizure
severe worsening of multiple sclerosis (MS) after stopping ZEPOSIA. When ZEPOSIA is stopped, symptoms of MS may return and become worse compared to before or during treatment. Always talk to your healthcare provider before you stop taking ZEPOSIA for any reason. Tell your healthcare provider if you have worsening symptoms of MS after stopping ZEPOSIA.

The most common side effects of ZEPOSIA can include:

upper respiratory tract infections
elevated liver enzymes
low blood pressure when you stand up (orthostatic hypotension)
painful and frequent urination (signs of urinary tract infection)
back pain
high blood pressure
headache

These are not all of the possible side effects of ZEPOSIA. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

INDICATIONS

Multiple Sclerosis (MS): ZEPOSIA^® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
Ulcerative Colitis (UC): ZEPOSIA is a prescription medicine used to treat moderately to severely active ulcerative colitis (UC) in adults.

It is not known if ZEPOSIA is safe and effective in children.

Please see full Prescribing Information, including Medication Guide.

Important Safety Information

Expand

+

Do not take ZEPOSIA if you:

have had a heart attack, chest pain (unstable angina), stroke or mini-stroke (transient ischemic attack or TIA), or certain types of heart failure in the last 6 months
have or have had a history of certain types of an irregular or abnormal heartbeat (arrhythmia) that is not corrected by a pacemaker
have untreated, severe breathing problems during your sleep (sleep apnea)

This website is best viewed using the vertical display on your mobile device.

This website is best viewed using the horizontal display on your tablet device.

Hear from adults

taking ZEPOSIA

Sign up

Other areas to explore:

Save on treatment costs

Want more information on ZEPOSIA?

Important Safety Information

Collapse

–

INDICATIONS

Important Safety Information

Expand

+

Save on
treatment costs