4 steps to getting started with ZEPOSIA
There are a few steps to getting started with ZEPOSIA. They will begin once your Start Form (your ZEPOSIA prescription) is submitted. Click below to see what you can expect.
If your start form was submitted to ZEPOSIA 360 SupportTM, a Support Coordinator will call to guide you through the support offerings and financial assistance options available to you. Consider adding this number to your phone so you can identify the call: 1-833-937-6742.
Our Support Coordinators can help with:
Navigating insurance benefits*
- Depending on your insurance coverage and financial needs, there may be several different ways to save on the cost of ZEPOSIA and the tests needed before treatment. Our Support Coordinators can help you understand your options
- If you have private or commercial insurance and experience delays with approvals, ask your Support Coordinator about the ZEPOSIA Bridge Program, which may be able to provide ZEPOSIA for free for up to 24 months†
Additional financial support options
- Eligible, commercially insured patients may pay as little as $0 a month for ZEPOSIA. Additional eligibility requirements and terms & conditions apply. Please click here for more information
- If you have difficulty affording your medication, our Support Coordinators can help you identify options that may be available to you
Additional support team members are also available to answer questions about ZEPOSIA and provide helpful resources.
1-833-ZEPOSIA (1-833-937-6742) Monday through Friday, 8 AM – 8 PM ET.
If you haven’t heard from a Support Coordinator, reach out to your healthcare team to ensure that your Start Form was submitted to ZEPOSIA 360 Support.
- The accurate completion of reimbursement or coverage related documentation is the responsibility of the healthcare provider and patient. BMS and its agents make no guarantee regarding reimbursement for any service or item.
- The Bridge Program is available at no cost for eligible, commercially insured, on-label diagnosed patients if there is a delay in determining whether commercial prescription coverage is available, and is not contingent on any purchase requirement, for up to 24 months (dispensed in 30-day increments). The Bridge Program is not available to patients who have prescription insurance coverage through a state or federal healthcare program, including but not limited to Medicare, Medicaid, Medigap, CHAMPUS, TRICARE, Veterans Affairs (VA), or Department of Defense (DoD) programs and is available for no more than 12 months to patients in MA, MN, and RI. Appeal of any prior authorization denial must be made within 90 days or as per payer guidelines, to remain in the program. Eligibility will be re-verified in January for patients continuing into the following year, and may be at other times during program participation. Offer is not health insurance. Once coverage is approved by the patient’s commercial insurance plan, the patient will no longer be eligible. Void where prohibited by law, taxed, or restricted. Bristol-Myers Squibb Company reserves the right to rescind, revoke, or amend this program at any time without notice. Other limitations may apply.
Did you know?
Did you know?
ZEPOSIA is covered for over 90% of people
with private or commercial health insurance.‡
This type of insurance is usually provided by an employer or a union, or purchased directly from an insurance company.
- Data provided by Bristol Myers Squibb and is current as of December 2022.
Before you start taking ZEPOSIA, two routine tests are required. If you have a history of certain eye conditions (macular edema or uveitis), or diabetes, you may also need an eye exam. Let your healthcare team know if you’ve had some of these tests within the last six months—they may not need to be repeated:
Blood work
Including complete blood count and liver function tests.
An electrocardiogram (ECG)
A common test that uses small sensors to monitor your heart and makes sure it’s working normally before you start treatment.
- These tests can be completed at your home, if you’re eligible.§ ZEPOSIA 360 Support can help schedule them
- Out-of-pocket costs may be eligible for reimbursement. There may be costs associated with some of the routine medical tests, but depending on where these tests take place, eligible patients may qualify for reimbursement. Additional eligibility requirements and terms & conditions apply. Please click here for more information
- Patient must have a valid prescription for ZEPOSIA for an FDA-approved indication. Patients are not eligible if they have prescription insurance coverage through a state or federal healthcare program, including but not limited to Medicare, Medicaid, Medigap, CHAMPUS, TRICARE, Veterans Affairs (VA), or Department of Defense (DoD) programs, or reside in Rhode Island. To receive the In-Home Medical Services Program, the prescriber must request in-home assessment assistance through the ZEPOSIA 360 Support program. The patient’s insurance will not be billed, and the patient will not be responsible for any out-of-pocket costs. Patients who move from commercial plans to state or federal healthcare programs will no longer be eligible. The program cannot be combined with any other offer, rebate, coupon, or free trial. The program is not conditioned on any past, present, or future purchase, including refills. Only valid in the United States and US Territories. Void where prohibited by law, taxed, or restricted. The program is not insurance. Bristol-Myers Squibb Company reserves the right to rescind, revoke, or amend this program at any time without notice. Other limitations may apply.
Once you’ve been approved to begin treatment, you’ll receive the ZEPOSIA Starter Kit. It will either be provided to you by your MS healthcare team or delivered directly to your home. Please see additional eligibility requirements and terms and conditions.||
The ZEPOSIA Starter Kit includes medication for the first 28 days of treatment and has two parts:

- A 7-day Starter Pack for your first week of treatment. The pills in this pack help increase your dosage of ZEPOSIA gradually. Each pill is labeled with the day and dosage. Be sure to follow the instructions written on the pack and take the pills in the correct order
- The regular dosage of ZEPOSIA (orange capsules) you’ll begin taking on day 8 (after completing the 7-day Starter Pack)
- Patient must have a valid prescription for ZEPOSIA for an FDA-approved indication. Patient must be new to therapy and have not previously received a sample or filled a prescription for ZEPOSIA. Patient is responsible for applicable taxes, if any. This offer is limited to one use per patient per lifetime and is non-transferable. Cannot be combined with any other rebate/coupon, free trial, or similar offer. No substitutions permitted. Patients, pharmacists, and prescribers cannot seek reimbursement for the ZEPOSIA Free Trial from health insurance or any third party, including state or federally funded programs. Patients may not count the ZEPOSIA Free Trial as an expense incurred for purposes of determining out-of-pocket costs for any plan, including Medicare Part D true out-of-pocket costs (TrOOP). Offer is not conditioned on any past, present, or future purchase, including refills. Only valid in the United States and US Territories. Void where prohibited by law or restricted. The program is not insurance. Bristol Myers Squibb reserves the right to rescind, revoke, or amend this offer at any time without notice.
You’ll receive a call from your specialty pharmacy A specialty pharmacy is different than a regular retail pharmacy. It distributes medications for certain chronic conditions and delivers them directly to you. Some specialty pharmacies also offer in-store pickup. to confirm the delivery of your ZEPOSIA prescription each month. If you prefer to pick up your prescription in store, simply ask your specialty pharmacy. They may offer that option.

The Support Coordinator worked with my specialty pharmacy to arrange delivery of ZEPOSIA directly to my home, which works great for me.
—Omar
A real ZEPOSIA patient compensated for his time.
(Individual results may vary.)