ZEPOSIA® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
It is not known if ZEPOSIA is safe and effective in children.
Please see full Prescribing Information and Medication Guide for ZEPOSIA.
ZEPOSIA is a once-daily pill for adults with relapsing multiple sclerosis (MS).
Take as directed by your doctor if certain liver problems exist.
ZEPOSIA is a once-daily pill for adults with relapsing multiple sclerosis (MS).
The signs of relapsing MS can be both visible, such as signs caused by relapses, and invisible, such as new or enlarging lesions. These signs vary from one person to the next and can even change in the same person over time. But understanding the condition better can help you and your healthcare provider find a treatment option that's right for you.
When talking to your healthcare provider, it’s important to discuss both the physical and cognitive symptoms of MS. Use the terms below as a tool to help with your MS research.
When a new MS symptom occurs, or an existing symptom gets worse, it’s defined as a “relapse” (or “exacerbation” or “flare-up”). This symptom must last more than 24 hours and be separated from the previous relapse by at least 30 days. The severity and duration of a relapse is often unpredictable. No 2 relapses are alike, but most last from a few days to several months.
An MS lesion is an area of damage or scarring that can occur throughout the central nervous system, including the brain.
Lesions often progress over time, and this progress is monitored by using magnetic resonance imaging (MRI) scans.
Everyone loses brain volume as they age, but for people with MS, it can happen more quickly. The brain is made up of white matter and grey matter.
Cognitive processing speed is a way to show how quickly the brain is able to receive information, process it correctly, and react to it.
Your healthcare provider may choose to measure your cognitive processing speed using the Multiple Sclerosis Functional Composite (MSFC), a common evaluation for people with MS, which is made up of 3 tests:
It’s important to discuss both the physical and cognitive symptoms of MS at your next appointment. So, how can you prepare?
(Section 1 of 3)
(Section 2 of 3)
(Section 3 of 3)
(Select all that apply)
Once a symptom is selected, indicate how it has changed in the last 6 months.
Feeling very tired or decreased strength
Numbness or tingling
Problems with coordination
Problems walking
Vision problems
Dizziness or vertigo
Sexual problems
Pain or muscle spasms
Speech problems
Bladder or bowel problems
Trouble remembering things
Difficulty concentrating
Emotional changes
Other
(Check all that apply)
Scroll down to review and save your personalized discussion guide. Sharing this information may help your MS healthcare team better manage your MS.
E-mail or download your responses below and share with your MS healthcare team at your next appointment.
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Keep this handy when talking with your MS healthcare team about treatment options. It can help guide the conversation.
I was diagnosed with MS:
Less than 1 year ago.
Not currently experiencing any symptoms.
I have experienced the following MS symptoms in the last 6 months:
Feeling very tired or decreased strength | Worse |
---|---|
Numbness or tingling | Same |
Problems with coordination | Better |
Problems walking | Increased |
Vision problems | Increased |
Dizziness | Same |
Sexual problems | Same |
Pain or muscle spasms | Same |
Speech problems | Same |
Bladder or bowel problems | Same |
Trouble remembering things | Same |
Difficulty concentrating | Same |
Emotional changes | Same |
Other | Same |
I am currently treating my MS.
I am very unsatisfied with my current treatment. There is room for improvement with my current treatment. I am satisfied with my current treatment.
The following are important to me when considering an MS medication:
How often the medication needs to be taken.
Whether the medication requires refrigeration.
Whether a treatment requires ongoing travel to a healthcare facility to be administered.
How affordable a mdication is (including availability of financial support options).
Additional questions to talk about with my MS healthcare team:
What impact could ZEPOSIA have on my MS?
What are the most common side effects?
Is ZEPOSIA a good option for me? Why?
In all types of MS, the body’s immune system attacks the central nervous system (CNS), which consists of the brain, the optic nerves, and the spinal cord.
Lesions disrupt the CNS and keep the brain from sending signals to the rest of the body. These “signal breakdowns” can lead to MS symptoms.
The nerves within the CNS are covered by a protective coating called myelin.
MS attacks the myelin, causing damage that can prevent the CNS from functioning like it should.
Although there is no way to predict relapsing MS from one person to another, there are three different common types of relapsing MS.
CIS is the first “episode” of MS symptoms. To be considered CIS, these symptoms must last at least
This is the most common form of MS, as 85% of people with MS are diagnosed with RRMS. This type of MS is defined by attacks of new or worsening neurological symptoms called “relapses.” Relapses can often be followed by periods of partial or complete recovery, called “remissions.”
RRMS can be categorized as “active” with relapses and or new MRI activity over a specific period of time, or “not active,” and as “worsening” with an increase in disability progression after experiencing a relapse or “not worsening.”
SPMS initially follows the course of RRMS, which can progress to “active SPMS.” This type of MS is categorized by frequent relapses and a progressive worsening of neurological function and disability over time.
One of the ways to help treat MS is with a type of medication called a disease-modifying therapy (DMT). Making healthy lifestyle choices is another way to help manage MS.
According to The Use of Disease-Modifying Therapies in Multiple Sclerosis, it is important to:
DMTs are not meant for managing MS symptoms day to day. However, there are other types of medications that can help. Talk to your MS healthcare team to learn more.
Making healthy lifestyle choices such as staying active, getting enough sleep, and eating right can help with MS. To learn more, visit CanDo-MS.org.
The information on this page comes from sources that include:
Brain health: time matters in multiple sclerosis
Giovannoni G, Butzkueven H, Dhib-Jalbut S, et al. Mult Scler Relat Disord. 2016;9(Suppl 1):S5-S48.
Cognitive changes
National Multiple Sclerosis Society.
Accessed February 7, 2024. https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Cognitive-Changes
Disease-modifying therapies for MS
National Multiple Sclerosis Society.
Accessed February 7, 2024. https://nms2cdn.azureedge.net/cmssite/nationalmssociety/media/msnationalfiles/brochures/brochure-the-ms-disease-modifying-medications.pdf
Managing relapses
National Multiple Sclerosis Society.
Accessed February 7, 2024. https://www.nationalmssociety.org/Treating-MS/Managing-Relapses
MS signs & symptoms
National Multiple Sclerosis Society.
Accessed February 7, 2024. https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms
Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis
Rae-Grant A, Day GS, Marrie RA, et al. Neurology. 2018;90(17):777-788.
The use of disease-modifying therapies in multiple sclerosis: principles and current evidence.
A consensus paper by the Multiple Sclerosis Coalition
Costello K, Kalb R.
Updated June 2019. Accessed February 7, 2024. http://www.nationalmssociety.org/getmedia/5ca284d3-fc7c-4ba5-b005-ab537d495c3c/DMT_Consensus_MS_Coalition_color