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ZEPOSIA® (ozanimod) is a prescription medicine used to treat moderately to severely active ulcerative colitis (UC) in adults.
It is not known if ZEPOSIA is safe and effective in children.
ZEPOSIA® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
It is not known if ZEPOSIA is safe and effective in children.
“I know now I need to be more on top of my UC so it doesn’t get on top of me.”
—Rosie
Retired professional soccer player
At the age of 18, Rosie was playing in an international game for the New Zealand national team when she experienced her first UC symptoms. Not understanding what was going on, she subbed herself off the field. She experienced symptoms of abnormal bowel function, pain, and blood in her stool. Some time and several doctors later, Rosie was diagnosed with UC.
Over the years, Rosie was prescribed suppositories, a variety of pills, and steroids to treat her UC. Whenever she started to feel better, she would stop taking her treatment as prescribed, thinking she no longer needed it. But then, her UC symptoms kept coming back.
When Rosie moved to Seattle, she met a new doctor who informed her that the inflammation in her colon had become much worse. Her doctor explained to her the importance of consistently taking medication—even when she wasn’t actively feeling as many of her symptoms. For the first time, Rosie began to think differently about her UC.
Rosie and her doctor discussed a variety of treatment options, including injections and infusions. Ultimately, based on Rosie’s busy lifestyle and regular travel, they decided once-daily ZEPOSIA would make sense for her.
Since starting treatment with ZEPOSIA, Rosie's follow-up colonoscopy showed that she was in remission. She has experienced symptom relief, which means less bleeding and less frequent diarrhea, and her doctor has seen improvements in the inflammation in her colon.*
With fewer symptoms, UC no longer dominates Rosie’s train of thought. Though she is now retired from playing soccer professionally, Rosie keeps busy as a private coach and an advocate of children's physical education.
Learn more about Rosie's conversation with her gastroenterologist
*
Individual results may vary. Click here to learn more about results from the clinical studies.
“Since starting ZEPOSIA, I have much more confidence in my treatment plan. It’s nice getting to do things on my time again.”
—Trey
Performer, gamer, fitness enthusiast
When Trey’s UC symptoms appeared, they interrupted his active social life and various hobbies. His journey with ZEPOSIA and ZEPOSIA 360 SupportTM helped him get back on track to doing the things he loves.
Whether he’s working out, playing video games, or cosplaying at conventions, Trey loves surrounding himself with good people. But when he started experiencing UC symptoms, Trey couldn’t go on drives, hikes, or even short walks without interruption. His doctor prescribed two pills and an enema—but within one year Trey’s symptoms started coming back.
Once Trey and his doctor discussed and he was prescribed ZEPOSIA, a clinician was sent directly to Trey's home to conduct his routine tests.* A UC Nurse Navigator from ZEPOSIA 360 Support also helped him get started, communicating directly with his insurance and pharmacy.
Since starting ZEPOSIA, Trey has experienced remission from his symptoms: no more blood in his stool, and his bathroom frequency has returned to normal.† With fewer symptoms interrupting his days, Trey can go on hikes again, go to conventions, and drive upstate to see his parents. He’s living life, uninterrupted.
*
Patient must have a valid prescription for ZEPOSIA for an FDA-approved indication. Patient must be commercially insured. Patients are not eligible if they have prescription insurance coverage through a state or federal healthcare program, including but not limited to Medicare, Medicaid, Medigap, CHAMPUS, TRICARE, Veterans Affairs (VA), or Department of Defense (DoD) programs, or reside in Rhode Island. To receive the In-Home Medical Services Program, the prescriber must request in-home assessment assistance through the ZEPOSIA 360 Support program. The patient’s insurance will not be billed, and the patient will not be responsible for any out-of-pocket costs. Patients who move from commercial plans to state or federal healthcare programs will no longer be eligible. The program cannot be combined with any other offer, rebate, coupon, or free trial. The program is not conditioned on any past, present, or future purchase, including refills. Only valid in the United States and US Territories. Void where prohibited by law, taxed, or restricted. The program is not insurance. Bristol-Myers Squibb Company reserves the right to rescind, revoke, or amend this program at any time without notice. Other limitations may apply.
†
Individual results may vary. Click here to learn more about results from the clinical studies.
“I remember for years just feeling up and down, just not in control...
I needed a change.”
—Amy
Mother, educator, and learner-at-heart
Though Amy has maintained remission* from her UC symptoms with ZEPOSIA, it has been a long journey of trial and error and self-advocacy to reach this point.
Amy was first diagnosed with UC in 2001 when her symptoms got so bad that she had to finish her college semester from home. Her GI prescribed two different medications, yet Amy could not find adequate symptom relief. She still experienced stomach pain, fatigue, and blood in her stool.
On and off steroids for years, Amy lived in a constant state of worry and questioning. Amy decided to seek out a new doctor, and she found one who treated her like a partner. Her new doctor told her that she had other options; he gave her a newfound confidence.
With her new doctor, Amy tried a variety of medications: pills, injections, infusions, and suppositories. And finally, her doctor recommended ZEPOSIA.
Within weeks, Amy was feeling better. Her symptoms went away—and stayed away.
Able to maintain remission, Amy is now sharing her story in hopes of helping others with UC. Though it was a long journey to symptom relief, by participating in organizations and support programs, Amy can use her experience to help others.
*
Individual results may vary. Click here to learn more about results from the clinical studies.
“It used to be a battle trying to get my UC symptoms under control.”
—Michael
Entrepreneur, recreational athlete, and husband
As a business owner, entrepreneur, and all-around fix-it man at home, Michael was highly motivated to find whatever solution he could to help treat his UC. As it progressed, his symptoms kept him from being fully present at work and at home. It seemed like no treatment would help. And then, after a long search, he and his doctor found ZEPOSIA.
Because of UC, Michael was frequently running to the bathroom throughout each day. He lost weight and stayed home more often. With his symptoms making it harder to work or enjoy the recreational activities he did before his diagnosis, he felt like he was no longer living so much as just managing his UC day after day.
For years, Michael and his doctor searched for the right treatment. Michael tried everything from enemas, to injections, to infusions, at one point taking multiple pills every day. He felt as if they had exhausted all treatment options.
Michael’s doctor, however, was determined to not give up. He recommended that Michael try ZEPOSIA, which had only recently become available.
Since starting ZEPOSIA, Michael has experienced early symptom reduction, which he has been able to maintain.* His life with UC looks much different than it once did. He once again enjoys some of his favorite activities, like biking, pickleball, and boating.
*
Individual results may vary. Click here to learn more about results from the clinical studies.
“Taking a once-daily pill has been great for me. It's easy for me to
remember—it’s the first thing I do in the morning.”
—Tim
Business owner, cyclist, and dog dad
It took years—and trying multiple treatments—before Tim could find lasting UC symptom relief, but he never gave up. After having open conversations with his doctor about his symptoms and the toll they were taking on his everyday life, Tim was prescribed ZEPOSIA—a once-daily pill that helped him reach remission.*
For Tim, a long-distance cyclist and business owner, the sudden appearance of UC was a shock. His professional life and hobbies were interrupted by severe symptoms of UC, and it was the first time he’d experienced a major health event.
Despite trying multiple medications, Tim struggled to find consistent relief. He even tried an injectable treatment, which reduced his symptoms at first—but they returned.
With his pain and frequent UC symptoms, Tim was unable to perform his job duties or see his friends and family. This years-long struggle took an emotional toll on him: he didn’t know when, or if, he’d ever feel better.
When Tim started seeing a new gastroenterologist, they discussed his treatment history, the symptoms he was having, and how they were affecting his life. That’s when Tim’s doctor told him about ZEPOSIA, a once-daily pill that worked differently than the other medications Tim had tried.
Since starting ZEPOSIA, Tim has achieved remission and has not experienced any flares. Without his debilitating symptoms, Tim has been able to return to his business and enjoy time with his friends and family again. He has even returned to his favorite hobby—long-distance cycling.
Watch a video to learn more about Tim’s story and how he and his doctor worked together to help him achieve his treatment goals.
*
Individual results may vary. Click here to learn more about results from the clinical studies.
Sharing your story can inspire others and make a big difference. When and how you participate is up to you, but by signing up, you can have the opportunity to share your story through videos, events, or more.
You can also sign up by calling 1-855-436-58661-855-436-5866.
Thank you!
Thank you for your interest in the ZEPOSIA Patient Ambassador program.
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Those who are eligible may
pay as little as $0 a month
for ZEPOSIA with a co-pay savings offer. View
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Sign up for the latest ZEPOSIA details, UC tips, stories from real people taking ZEPOSIA, and more from ZEPOSIA 360 Support.
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Do not take ZEPOSIA if you:
Talk to your healthcare provider before taking ZEPOSIA if you have any of these conditions or do not know if you have any of these conditions.
ZEPOSIA may cause serious side effects, including:
Call your healthcare provider right away if you have any of these symptoms of an infection during treatment with ZEPOSIA and for 3 months after your last dose of ZEPOSIA:
Your healthcare provider may delay starting or may stop your ZEPOSIA treatment if you have an infection.
Progressive multifocal leukoencephalopathy (PML). ZEPOSIA can increase your risk for PML, which is a rare brain infection that usually leads to death or severe disability. If PML happens, it usually happens in people with weakened immune systems but has happened in people who do not have weakened immune systems. Symptoms of PML get worse over days to weeks. Call your doctor right away if you have any new or worsening symptoms of PML that have lasted several days, including: weakness on one (1) side of your body, changes in your vision, changes in your thinking or memory, confusion, changes in your personality, loss of coordination in your arms or legs, decreased strength, and/or problems with balance.
Call your healthcare provider if you experience the following symptoms of slow heart rate:
Follow directions from your healthcare provider when starting ZEPOSIA and when you miss a dose.
Continue reading for additional possible serious side effects of ZEPOSIA.
Before taking ZEPOSIA, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take or have recently taken, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using ZEPOSIA with other medicines can cause serious side effects. Especially tell your healthcare provider if you take or have taken:
You should not receive live vaccines during treatment with ZEPOSIA, for at least 1 month before taking ZEPOSIA and for 3 months after you stop taking ZEPOSIA. Vaccines may not work as well when given during treatment with ZEPOSIA.
ZEPOSIA can cause serious side effects, including:
The most common side effects of ZEPOSIA can include:
These are not all of the possible side effects of ZEPOSIA. For more information, ask your healthcare provider or pharmacist.
Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 1-800-FDA-1088.
Multiple Sclerosis (MS): ZEPOSIA® (ozanimod) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
Ulcerative Colitis (UC): ZEPOSIA is a prescription medicine used to treat moderately to severely active ulcerative colitis (UC) in adults.
It is not known if ZEPOSIA is safe and effective in children.
Please see full Prescribing Information, including Medication Guide.
Do not take ZEPOSIA if you:
Talk to your healthcare provider before taking ZEPOSIA if you have any of these conditions or do not know if you have any of these conditions.
ZEPOSIA may cause serious side effects, including: